ENSMUSG00000024425


Mus musculus

Features
Gene ID: ENSMUSG00000024425
  
Biological name :Ndfip1
  
Synonyms : Ndfip1 / NEDD4 family-interacting protein 1 / Q8R0W6
  
Possible biological names infered from orthology : Q9BT67
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: B3
Gene start: 38418975
Gene end: 38464399
  
Corresponding Affymetrix probe sets: 10455238 (MoGene1.0st)   1424820_a_at (Mouse Genome 430 2.0 Array)   1424821_at (Mouse Genome 430 2.0 Array)   1451493_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025293
NCBI entrez gene - 65113     See in Manteia.
MGI - MGI:1929601
RefSeq - XM_006526149
RefSeq - NM_022996
RefSeq Peptide - NP_075372
RefSeq Peptide - NP_001342678
swissprot - Q8R0W6
Ensembl - ENSMUSG00000024425
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ndfip1ENSDARG00000013979Danio rerio
 Q6DGP4ENSDARG00000102367Danio rerio
 NDFIP1ENSGALG00000043744Gallus gallus
 NDFIP1ENSG00000131507Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ndfip2 / Nedd4 family interacting protein 2 / Q9NV92*ENSMUSG0000005325357


Protein motifs (from Interpro)
Interpro ID Name
 IPR019325  NEDD4/Bsd2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002761 regulation of myeloid leukocyte differentiation IMP
 biological_processGO:0002829 negative regulation of type 2 immune response IMP
 biological_processGO:0006879 cellular iron ion homeostasis IEA
 biological_processGO:0007034 vacuolar transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0030001 metal ion transport IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0032410 negative regulation of transporter activity IEA
 biological_processGO:0032713 negative regulation of interleukin-4 production IMP
 biological_processGO:0042130 negative regulation of T cell proliferation IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
 biological_processGO:0045619 regulation of lymphocyte differentiation IMP
 biological_processGO:0045732 positive regulation of protein catabolic process IMP
 biological_processGO:0048294 negative regulation of isotype switching to IgE isotypes IMP
 biological_processGO:0048302 regulation of isotype switching to IgG isotypes IMP
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 biological_processGO:0051224 negative regulation of protein transport IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISM
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030173 integral component of Golgi membrane IC
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000172 abnormal bone marrow cell number "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000466 esophageal epithelium hyperplasia "increased cell number in the epithelial layer of the esophagus" [J:47225]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0000468 abnormal esophageal epithelium morphology "malformation of the epithelial layer of the esophagus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ndfip1tm1.1Pmo/Ndfip1tm1.1Pmo,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002928 abnormal bile duct morphology "malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0003278 esophageal inflammation "local accumulation of fluid, plasma proteins and leukocytes in the esophagus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Ndfip1tm1.1Pmo/Ndfip1tm1.1Pmo,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ndfip1tm1.1Pmo/Ndfip1tm1.1Pmo,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Ndfip1tm1.1Pmo/Ndfip1tm1.1Pmo,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0005637 abnormal iron homeostasis "anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64456]
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Allelic Composition: Grhl3tm1Bogi/Grhl3+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0006060 increased cerebral infarction size "increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Epm2atm1Kzy/Epm2atm1Kzy
Genetic Background: involves: 129P2/OlaHsd

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0008090 increased T-helper 2 cell number "greater number of the subset of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Themism1Btlr/Themism1Btlr
Genetic Background: C57BL/6J-Themism1Btlr

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0010945 lung epithelium hyperplasia "overdevelopment or increased size, usually due an increased number of cells in the epithelial layer of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0011451 increased susceptibility to dopaminergic neuron neurotoxicity "greater than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith]
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Allelic Composition: Grhl3tm1Bogi/Grhl3+
Genetic Background: involves: C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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