ENSMUSG00000024426


Mus musculus

Features
Gene ID: ENSMUSG00000024426
  
Biological name :Atat1
  
Synonyms : Atat1 / Mus musculus alpha tubulin acetyltransferase 1 (Atat1), transcript variant 5, mRNA. / Q8K341
  
Possible biological names infered from orthology : alpha tubulin acetyltransferase 1 / Q5SQI0
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B1
Gene start: 35897595
Gene end: 35910075
  
Corresponding Affymetrix probe sets: 10450622 (MoGene1.0st)   1429006_s_at (Mouse Genome 430 2.0 Array)   1429603_at (Mouse Genome 430 2.0 Array)   1435381_at (Mouse Genome 430 2.0 Array)   1452979_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122715
Ensembl peptide - ENSMUSP00000122211
Ensembl peptide - ENSMUSP00000122626
Ensembl peptide - ENSMUSP00000053853
Ensembl peptide - ENSMUSP00000056383
Ensembl peptide - ENSMUSP00000076703
Ensembl peptide - ENSMUSP00000115004
Ensembl peptide - ENSMUSP00000117824
Ensembl peptide - ENSMUSP00000119039
NCBI entrez gene - 73242     See in Manteia.
MGI - MGI:1913869
RefSeq - XM_017317676
RefSeq - NM_001357865
RefSeq - NM_028476
RefSeq - XM_006524989
RefSeq - XM_006524991
RefSeq - XM_011246654
RefSeq - XM_017317671
RefSeq - XM_017317672
RefSeq - XM_017317673
RefSeq - XM_017317674
RefSeq - XM_017317675
RefSeq - NM_001142744
RefSeq - NM_001142745
RefSeq - NM_001347378
RefSeq Peptide - NP_001136217
RefSeq Peptide - NP_001334307
RefSeq Peptide - NP_001344794
RefSeq Peptide - NP_082752
RefSeq Peptide - NP_001136216
swissprot - F7BUT2
swissprot - F7CID0
swissprot - F6RPX5
swissprot - Q8K341
swissprot - B8JJ72
Ensembl - ENSMUSG00000024426
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atat1ENSDARG00000004472Danio rerio
 ATAT1ENSG00000137343Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007965  Gcn5-related N-acetyltransferase (GNAT) domain, ATAT-type
 IPR016181  Acyl-CoA N-acyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0021542 dentate gyrus development IMP
 biological_processGO:0045598 regulation of fat cell differentiation IMP
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IBA
 biological_processGO:0071929 alpha-tubulin acetylation IEA
 biological_processGO:1900227 positive regulation of NLRP3 inflammasome complex assembly IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0072686 mitotic spindle ISO
 cellular_componentGO:0097427 microtubule bundle IDA
 molecular_functionGO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0019799 tubulin N-acetyltransferase activity IEA
 molecular_functionGO:0050662 coenzyme binding ISO


Pathways (from Reactome)
Pathway description
Cilium Assembly


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cavin3tm1(KOMP)Vlcg/Cavin3tm1(KOMP)Vlcg,Cavin2tm1(KOMP)Vlcg/Cavin2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Dgcr8Gt(XG058)Byg/Dgcr8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
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Allelic Composition: Dgcr8Gt(XG058)Byg/Dgcr8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Cavin3tm1(KOMP)Vlcg/Cavin3tm1(KOMP)Vlcg,Cavin2tm1(KOMP)Vlcg/Cavin2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cavin3tm1(KOMP)Vlcg/Cavin3tm1(KOMP)Vlcg,Cavin2tm1(KOMP)Vlcg/Cavin2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cavin3tm1(KOMP)Vlcg/Cavin3tm1(KOMP)Vlcg,Cavin2tm1(KOMP)Vlcg/Cavin2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cavin3tm1(KOMP)Vlcg/Cavin3tm1(KOMP)Vlcg,Cavin2tm1(KOMP)Vlcg/Cavin2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Cavin3tm1(KOMP)Vlcg/Cavin3tm1(KOMP)Vlcg,Cavin2tm1(KOMP)Vlcg/Cavin2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Cavin3tm1(KOMP)Vlcg/Cavin3tm1(KOMP)Vlcg,Cavin2tm1(KOMP)Vlcg/Cavin2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cavin3tm1(KOMP)Vlcg/Cavin3tm1(KOMP)Vlcg,Cavin2tm1(KOMP)Vlcg/Cavin2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0004929 decreased epididymis weight "reduction in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cavin3tm1(KOMP)Vlcg/Cavin3tm1(KOMP)Vlcg,Cavin2tm1(KOMP)Vlcg/Cavin2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Cavin3tm1(KOMP)Vlcg/Cavin3tm1(KOMP)Vlcg,Cavin2tm1(KOMP)Vlcg/Cavin2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Dgcr8Gt(XG058)Byg/Dgcr8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cavin3tm1(KOMP)Vlcg/Cavin3tm1(KOMP)Vlcg,Cavin2tm1(KOMP)Vlcg/Cavin2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0009239 short sperm flagellum "decreased length of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cavin3tm1(KOMP)Vlcg/Cavin3tm1(KOMP)Vlcg,Cavin2tm1(KOMP)Vlcg/Cavin2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0009834 abnormal sperm annulus morphology "any structural anomaly of the ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity" [PMID:14581499]
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Allelic Composition: Cavin3tm1(KOMP)Vlcg/Cavin3tm1(KOMP)Vlcg,Cavin2tm1(KOMP)Vlcg/Cavin2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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