ENSMUSG00000024430


Mus musculus

Features
Gene ID: ENSMUSG00000024430
  
Biological name :Cabyr
  
Synonyms : Cabyr / Calcium-binding tyrosine phosphorylation-regulated protein / Q9D424
  
Possible biological names infered from orthology : calcium binding tyrosine phosphorylation regulated / O75952
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: A1
Gene start: 12741324
Gene end: 12755146
  
Corresponding Affymetrix probe sets: 10454030 (MoGene1.0st)   1424558_a_at (Mouse Genome 430 2.0 Array)   1430007_a_at (Mouse Genome 430 2.0 Array)   1451946_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000079277
Ensembl peptide - ENSMUSP00000111523
Ensembl peptide - ENSMUSP00000113131
Ensembl peptide - ENSMUSP00000113760
Ensembl peptide - ENSMUSP00000118330
Ensembl peptide - ENSMUSP00000140870
Ensembl peptide - ENSMUSP00000140894
NCBI entrez gene - 71132     See in Manteia.
MGI - MGI:1918382
RefSeq - XM_017317979
RefSeq - NM_001042418
RefSeq - NM_001042419
RefSeq - NM_001042420
RefSeq - NM_027687
RefSeq - NM_181731
RefSeq Peptide - NP_859420
RefSeq Peptide - NP_001035885
RefSeq Peptide - NP_081963
RefSeq Peptide - NP_001035884
RefSeq Peptide - NP_001035883
swissprot - Q9D424
swissprot - Q3KNH8
Ensembl - ENSMUSG00000024430
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABYRENSG00000154040Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003117  cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019722 calcium-mediated signaling NAS
 biological_processGO:0048240 sperm capacitation NAS
 biological_processGO:0051259 protein complex oligomerization NAS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0031514 motile cilium ISS
 cellular_componentGO:0035686 sperm fibrous sheath IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0097228 sperm principal piece IDA
 cellular_componentGO:0097229 sperm end piece IDA
 molecular_functionGO:0005509 calcium ion binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding ISS
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Golga5em3Lanyu/Golga5em3Lanyu,Golgb1em8Lanyu/Golgb1em8Lanyu
Genetic Background: FVB/NJ-Golga5em3Lanyu Golgb1em8Lanyu

 MP:0002674 abnormal sperm motility "anomalies in the mobility of the spermatozoa" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Golga5em3Lanyu/Golga5em3Lanyu,Golgb1em8Lanyu/Golgb1em8Lanyu
Genetic Background: FVB/NJ-Golga5em3Lanyu Golgb1em8Lanyu

 MP:0003666 impaired sperm capacitation "anomaly in the change undergone by spermatozoa in the female genital tract that enables them to penetrate and fertilize an egg" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96669]
Show

Allelic Composition: Golga5em3Lanyu/Golga5em3Lanyu,Golgb1em8Lanyu/Golgb1em8Lanyu
Genetic Background: FVB/NJ-Golga5em3Lanyu Golgb1em8Lanyu

 MP:0003698 abnormal male reproductive system physiology "anomaly in the function of the male organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Golga5em3Lanyu/Golga5em3Lanyu,Golgb1em8Lanyu/Golgb1em8Lanyu
Genetic Background: FVB/NJ-Golga5em3Lanyu Golgb1em8Lanyu

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Golga5em3Lanyu/Golga5em3Lanyu,Golgb1em8Lanyu/Golgb1em8Lanyu
Genetic Background: FVB/NJ-Golga5em3Lanyu Golgb1em8Lanyu

 MP:0009280 reduced activated sperm motility "loss or reduction of the activated type of sperm mobility, resulting in immotile sperm that are generally unable to reach the uterotubal junction; decreases in activated sperm motility may result in reduced male fertility" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Golga5em3Lanyu/Golga5em3Lanyu,Golgb1em8Lanyu/Golgb1em8Lanyu
Genetic Background: FVB/NJ-Golga5em3Lanyu Golgb1em8Lanyu

 MP:0009836 abnormal sperm principal piece morphology "any structural abnormality in the segment of the sperm flagellum where the mitochondrial sheath ends and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs; the principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece" [PMID:14581499]
Show

Allelic Composition: Golga5em3Lanyu/Golga5em3Lanyu,Golgb1em8Lanyu/Golgb1em8Lanyu
Genetic Background: FVB/NJ-Golga5em3Lanyu Golgb1em8Lanyu

 MP:0009838 abnormal sperm axoneme morphology "any structural abnormality of the central core of the sperm flagellum, composed of a ring of 9 outer microtubule doublets surrounding a central pair; inner and outer dynein arms project from each of the outer 9 doublets, and these arms are responsible for generating the motive force of the flagellum; in addition, 9 radial spokes, each of which originates from 1 of the 9 outer microtubular doublet pairs, project inward toward the central pair in a helical fashion" [PMID:14581499]
Show

Allelic Composition: Golga5em3Lanyu/Golga5em3Lanyu,Golgb1em8Lanyu/Golgb1em8Lanyu
Genetic Background: FVB/NJ-Golga5em3Lanyu Golgb1em8Lanyu

 MP:0020451 decreased sperm progressive motility "decrease in the ability of sperm to move in a more or less straight line" [MGI:smb]
Show

Allelic Composition: Golga5em3Lanyu/Golga5em3Lanyu,Golgb1em8Lanyu/Golgb1em8Lanyu
Genetic Background: FVB/NJ-Golga5em3Lanyu Golgb1em8Lanyu

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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