ENSMUSG00000024500


Mus musculus

Features
Gene ID: ENSMUSG00000024500
  
Biological name :Ppp2r2b
  
Synonyms : Ppp2r2b / protein phosphatase 2, regulatory subunit B, beta / Q6ZWR4
  
Possible biological names infered from orthology : protein phosphatase 2 regulatory subunit Bbeta / Q00005
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: B3
Gene start: 42637432
Gene end: 43059471
  
Corresponding Affymetrix probe sets: 10458645 (MoGene1.0st)   1426621_a_at (Mouse Genome 430 2.0 Array)   1446036_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025377
Ensembl peptide - ENSMUSP00000113411
Ensembl peptide - ENSMUSP00000113731
NCBI entrez gene - 72930     See in Manteia.
MGI - MGI:1920180
RefSeq - NM_028392
RefSeq Peptide - NP_082668
swissprot - Q6ZWR4
Ensembl - ENSMUSG00000024500
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp2r2baENSDARG00000100093Danio rerio
 ppp2r2bbENSDARG00000099221Danio rerio
 PPP2R2BENSGALG00000007565Gallus gallus
 Q00005ENSG00000156475Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6P1F6 / Ppp2r2a / protein phosphatase 2, regulatory subunit B, alpha / P63151* / protein phosphatase 2 regulatory subunit Balpha*ENSMUSG0000002205284
Q925E7 / Ppp2r2d / protein phosphatase 2, regulatory subunit B, delta / Q66LE6* / protein phosphatase 2 regulatory subunit Bdelta*ENSMUSG0000004176983
Q8BG02 / Ppp2r2c / protein phosphatase 2, regulatory subunit B, gamma / Q9Y2T4* / protein phosphatase 2 regulatory subunit Bgamma*ENSMUSG0000002912082


Protein motifs (from Interpro)
Interpro ID Name
 IPR000009  Protein phosphatase 2A regulatory subunit PR55
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR018067  Protein phosphatase 2A regulatory subunit PR55, conserved site
 IPR019775  WD40 repeat, conserved site
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IBA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0032502 developmental process IBA
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0070262 peptidyl-serine dephosphorylation IBA
 cellular_componentGO:0000159 protein phosphatase type 2A complex IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISS
 cellular_componentGO:0005741 mitochondrial outer membrane ISS
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019888 protein phosphatase regulator activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pitpnm1tm1a(EUCOMM)Wtsi/Pitpnm1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pitpnm1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Pitpnm1tm1a(EUCOMM)Wtsi/Pitpnm1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pitpnm1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pitpnm1tm1a(EUCOMM)Wtsi/Pitpnm1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pitpnm1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005628 decreased circulating potassium level "less than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
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Allelic Composition: Pitpnm1tm1a(EUCOMM)Wtsi/Pitpnm1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pitpnm1tm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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