ENSMUSG00000024552


Mus musculus

Features
Gene ID: ENSMUSG00000024552
  
Biological name :Slc14a2
  
Synonyms : Slc14a2 / urea transporter 2 isoform b
  
Possible biological names infered from orthology : Q15849 / solute carrier family 14 member 2
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: E3
Gene start: 78146940
Gene end: 78209094
  
Corresponding Affymetrix probe sets: 10459879 (MoGene1.0st)   1425250_a_at (Mouse Genome 430 2.0 Array)   1426109_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025434
Ensembl peptide - ENSMUSP00000126416
NCBI entrez gene - 27411     See in Manteia.
MGI - MGI:1351653
RefSeq - XM_017317915
RefSeq - NM_001110274
RefSeq - NM_030683
RefSeq - NM_207651
RefSeq - XM_006526488
RefSeq Peptide - NP_001103744
RefSeq Peptide - NP_109608
RefSeq Peptide - NP_997534
swissprot - G5E849
swissprot - A0A0R4J213
Ensembl - ENSMUSG00000024552
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-183c6.7ENSDARG00000102029Danio rerio
 slc14a2ENSDARG00000051914Danio rerio
 SLC14A2ENSGALG00000032749Gallus gallus
 Q15849ENSG00000132874Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8VHL0 / Slc14a1 / Urea transporter 1 / Q13336* / solute carrier family 14 member 1 (Kidd blood group)*ENSMUSG0000005933627


Protein motifs (from Interpro)
Interpro ID Name
 IPR004937  Urea transporter
 IPR029020  Ammonium/urea transporter


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0071918 urea transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0015204 urea transmembrane transporter activity IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA


Pathways (from Reactome)
Pathway description
Transport of bile salts and organic acids, metal ions and amine compounds


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000532 kidney vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the organ of secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Aprttm1Jat/Aprt+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Aprttm1Jat/Aprt+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Slc14a1tm1Ask/Slc14a1tm1Ask,Slc14a2tm1Bxy/Slc14a2tm1Bxy
Genetic Background: involves: C57BL/6J

Allelic Composition: Slc14a2tm1Raf/Slc14a2tm1Raf
Genetic Background: B6.129S6-Slc14a2tm1Raf

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Slc14a2tm1Suc/Slc14a2tm1Suc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Slc14a1tm1Ask/Slc14a1tm1Ask,Slc14a2tm1Bxy/Slc14a2tm1Bxy
Genetic Background: involves: C57BL/6J

Allelic Composition: Slc14a2tm1Raf/Slc14a2tm1Raf
Genetic Background: B6.129S6-Slc14a2tm1Raf

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Slc14a2tm1Raf/Slc14a2tm1Raf
Genetic Background: B6.129S6-Slc14a2tm1Raf

 MP:0004851 increased testis weight "greater average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc14a2tm1Raf/Slc14a2tm1Raf
Genetic Background: B6.129S6-Slc14a2tm1Raf

 MP:0005524 abnormal renal plasma flow rate "deviation from the normal volume of plasma passing throught the kidney per unit time" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc14a2tm1Raf/Slc14a2tm1Raf
Genetic Background: B6.129S6-Slc14a2tm1Raf

 MP:0005556 abnormal kidney clearance "altered ability of the kidneys to remove substances from the plasma for excretion in a specific period of time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc14a1tm1Ask/Slc14a1tm1Ask,Slc14a2tm1Bxy/Slc14a2tm1Bxy
Genetic Background: involves: C57BL/6J

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc14a1tm1Ask/Slc14a1tm1Ask,Slc14a2tm1Bxy/Slc14a2tm1Bxy
Genetic Background: involves: C57BL/6J

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc14a2tm1Raf/Slc14a2tm1Raf
Genetic Background: B6.129S6-Slc14a2tm1Raf

 MP:0011417 abnormal renal transport "any anomaly of the directed movement of substances through the kidney" [MGI:csmith]
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Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Slc14a2tm1Suc/Slc14a2tm1Suc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Slc14a2tm1Raf/Slc14a2tm1Raf
Genetic Background: B6.129S6-Slc14a2tm1Raf

 MP:0011431 increased urine flow rate "increased volume of urine produced in a specified period of time" [MGI:anna]
Show

Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Slc14a2tm1Raf/Slc14a2tm1Raf
Genetic Background: B6.129S6-Slc14a2tm1Raf

 MP:0011466 increased urine urea nitrogen level "abnormally high amounts of nitrogen in the form of urea in the urine" [MGI:csmith]
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Allelic Composition: Slc14a2tm1Raf/Slc14a2tm1Raf
Genetic Background: B6.129S6-Slc14a2tm1Raf

 MP:0011471 decreased urine creatinine level "a reduced amount of creatinine in the urine compared to the normal state" [MGI:csmith]
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Allelic Composition: Slc14a1tm1Ask/Slc14a1tm1Ask,Slc14a2tm1Bxy/Slc14a2tm1Bxy
Genetic Background: involves: C57BL/6J

 MP:0011741 increased urine nitrite level "higher than normal amount of nitrite (NO2-) in the urine, usually indicative of a urinary tract infection; commonly a result of the action of Escherichia coli, Proteus vulgaris, and other microorganisms that may reduce nitrates" [MGI:anna]
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Allelic Composition: Slc14a2tm1Raf/Slc14a2tm1Raf
Genetic Background: B6.129S6-Slc14a2tm1Raf

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Slc14a1tm1Ask/Slc14a1tm1Ask,Slc14a2tm1Bxy/Slc14a2tm1Bxy
Genetic Background: involves: C57BL/6J

Allelic Composition: Slc14a2tm1Raf/Slc14a2tm1Raf
Genetic Background: B6.129S6-Slc14a2tm1Raf

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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