ENSMUSG00000024560


Mus musculus

Features
Gene ID: ENSMUSG00000024560
  
Biological name :Cxxc1
  
Synonyms : Cxxc1 / CXXC-type zinc finger protein 1 / Q9CWW7
  
Possible biological names infered from orthology : CXXC finger protein 1 / Q9P0U4
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E2
Gene start: 74216131
Gene end: 74221491
  
Corresponding Affymetrix probe sets: 10456601 (MoGene1.0st)   1452221_a_at (Mouse Genome 430 2.0 Array)   1454106_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025444
NCBI entrez gene - 74322     See in Manteia.
MGI - MGI:1921572
RefSeq - XM_006526302
RefSeq - NM_028868
RefSeq Peptide - NP_083144
swissprot - Q541B1
swissprot - Q9CWW7
Ensembl - ENSMUSG00000024560
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cxxc1aENSDARG00000101996Danio rerio
 cxxc1bENSDARG00000025718Danio rerio
 CXXC1ENSG00000154832Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR002857  Zinc finger, CXXC-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR022056  CpG binding protein, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0051568 histone H3-K4 methylation IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016363 nuclear matrix IDA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0035097 histone methyltransferase complex IEA
 cellular_componentGO:0048188 Set1C/COMPASS complex ISS
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0042800 histone methyltransferase activity (H3-K4 specific) IEA
 molecular_functionGO:0045322 unmethylated CpG binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
Show

Allelic Composition: Zeb1Tw/Zeb1Tw
Genetic Background: involves: C57BL/6J

 MP:0005032 abnormal ectoplacental cone 
Show

Allelic Composition: Zeb1Tw/Zeb1Tw
Genetic Background: involves: C57BL/6J

 MP:0009687 empty decidua capsularis "the implanted embryo normally covered opposite the placenta by uterine mucosa and epithelium following implantation is missing, suggesting the embryo died early during implantation but after the decidual response and modification of uterine stromal cells" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zeb1Tw/Zeb1Tw
Genetic Background: involves: C57BL/6J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Zeb1Tw/Zeb1Tw
Genetic Background: involves: C57BL/6J

 MP:0011184 absent embryonic epiblast "absence of the tissue derived from the inner cell mass that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper and to the extraembryonic mesoderm" [PMID:21123814]
Show

Allelic Composition: Zeb1Tw/Zeb1Tw
Genetic Background: involves: C57BL/6J

 MP:0013207 absent endoderm "absence of the innermost of the three primary germ layers of the embryo (the others being mesoderm and ectoderm) that is formed during gastrulation" [MGI:anna]
Show

Allelic Composition: Zeb1Tw/Zeb1Tw
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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