ENSMUSG00000024653


Mus musculus

Features
Gene ID: ENSMUSG00000024653
  
Biological name :Scgb1a1
  
Synonyms : Q06318 / Scgb1a1 / secretoglobin, family 1A, member 1 (uteroglobin)
  
Possible biological names infered from orthology : P11684 / secretoglobin family 1A member 1
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 9083636
Gene end: 9087958
  
Corresponding Affymetrix probe sets: 10465840 (MoGene1.0st)   1452543_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025554
NCBI entrez gene - 22287     See in Manteia.
MGI - MGI:98919
RefSeq - NM_011681
RefSeq Peptide - NP_035811
swissprot - Q06318
swissprot - Q3UKV9
Ensembl - ENSMUSG00000024653
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P11684ENSG00000149021Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000329  Uteroglobin
 IPR016126  Secretoglobin
 IPR035960  Secretoglobin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0009410 response to xenobiotic stimulus IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010193 response to ozone IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032689 negative regulation of interferon-gamma production IDA
 biological_processGO:0032696 negative regulation of interleukin-13 production IMP
 biological_processGO:0032713 negative regulation of interleukin-4 production IMP
 biological_processGO:0032714 negative regulation of interleukin-5 production IMP
 biological_processGO:0034021 response to silicon dioxide IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0042130 negative regulation of T cell proliferation IDA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 biological_processGO:0043488 regulation of mRNA stability IDA
 biological_processGO:0050727 regulation of inflammatory response IDA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0071774 response to fibroblast growth factor IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0030141 secretory granule IEA
 molecular_functionGO:0019834 phospholipase A2 inhibitor activity IEA
 molecular_functionGO:0097160 polychlorinated biphenyl binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Grhl3ct/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * C57BL/6 * STOCK ct/J

 MP:0000523 cortical glomerulopathies "any disease of the capillary plexus in the kidney cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
Show

Allelic Composition: Grhl3ct/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * C57BL/6 * STOCK ct/J

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Krastm4Tyj/Kras+,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Grhl3ct/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * C57BL/6 * STOCK ct/J

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Rettm1Cos/Rettm2(RET)Jmi
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
Show

Allelic Composition: Krastm4Tyj/Kras+,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Krastm4Tyj/Kras+,Scgb1a1tm1(cre/ERT)Blh/Scgb1a1+,Trp53tm5Tyj/Trp53+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Krastm4Tyj/Kras+,Scgb1a1tm1(cre/ERT)Blh/Scgb1a1+,Trp53tm5Tyj/Trp53+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0002132 abnormal respiratory system morphology "anomalous structure of pulmonary tissues " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grhl3ct/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * C57BL/6 * STOCK ct/J

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxp1tm1.1Pwt/Foxp1tm1.1Pwt,Foxp4tm2.1Eem/Foxp4tm2.1Eem,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grhl3ct/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * C57BL/6 * STOCK ct/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmi1tm1(cre/ERT)Mrc/Bmi1+,Ctnnb1tm1Mmt/Ctnnb1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Scgb1a1tm1.1(cre)Fjd/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Scgb1a1tm1(cre/ERT)Blh/Scgb1a1+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEv * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002277 abnormal respiratory mucosa morphology "structural anomaly of the mucous membrane lining the respiratory tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sortm1(Notch1)Dam
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Scgb1a1tm1Brst/Scgb1a1tm1Brst
Genetic Background: involves: 129P2/OlaHsd * 129P3/J

Allelic Composition: Scgb1a1tm1Brst/Scgb1a1tm1Brst
Genetic Background: involves: 129P2/OlaHsd * 129P3/J * C57BL/6

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Grhl3ct/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * C57BL/6 * STOCK ct/J

 MP:0003115 abnormal respiratory system development "aberrant differentiation of pulmonary tissues" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxp1tm1.1Pwt/Foxp1tm1.1Pwt,Foxp4tm2.1Eem/Foxp4tm2.1Eem,Scgb1a1tm1(icre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004390 abnormal bronchoalveolar duct junctions "any structural anomaly of the branch point connecting the respiratory bronchioles to the alveolar ducts" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm4Tyj/Kras+,Scgb1a1tm1(cre/ERT)Blh/Scgb1a1+,Trp53tm5Tyj/Trp53+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grhl3ct/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * C57BL/6 * STOCK ct/J

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxp1tm1.1Pwt/Foxp1tm1.1Pwt,Foxp4tm2.1Eem/Foxp4tm2.1Eem,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005426 tachypnea "rapid breathing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0005488 bronchial epithelial hyperplasia "increased numbers of cells lining the inner surfaces of the bronchi" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rettm1Cos/Rettm2(RET)Jmi
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh/Gt(ROSA)26Sor+,Scgb1a1tm1(cre/ERT)Blh/Scgb1a1+
Genetic Background: involves: 129S6/SvEv * C57BL/6

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm4Tyj/Kras+,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0008714 lung carcinoma "a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0008875 abnormal pharmacokinetics of xenobiotics "any anomaly in the absorbtion, distribution, metabolism or elimination of a foreign compound" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sortm1(Notch1)Dam
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Scgb1a1tm1Brst/Scgb1a1tm1Brst
Genetic Background: involves: 129P2/OlaHsd * 129P3/J

Allelic Composition: Scgb1a1tm1Brst/Scgb1a1tm1Brst
Genetic Background: involves: 129P2/OlaHsd * 129P3/J * C57BL/6

 MP:0009148 pancreas necrosis "pathological cell death in the pancreas, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grhl3ct/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * C57BL/6 * STOCK ct/J

 MP:0009308 adenocarcinoma "malignant neoplasm of epithelial cells in a glandular or glandular-like pattern" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Krastm4Tyj/Kras+,Scgb1a1tm1(cre/ERT)Blh/Scgb1a1+,Trp53tm5Tyj/Trp53+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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