ENSMUSG00000024669


Mus musculus

Features
Gene ID: ENSMUSG00000024669
  
Biological name :Cd5
  
Synonyms : Cd5 / P13379 / T-cell surface glycoprotein CD5
  
Possible biological names infered from orthology : CD5 molecule / P06127
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 10718143
Gene end: 10738974
  
Corresponding Affymetrix probe sets: 10466040 (MoGene1.0st)   1418353_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025571
NCBI entrez gene - 12507     See in Manteia.
MGI - MGI:88340
RefSeq - XM_006526621
RefSeq - NM_007650
RefSeq Peptide - NP_031676
swissprot - P13379
swissprot - Q3UP78
Ensembl - ENSMUSG00000024669
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD5ENSGALG00000031735Gallus gallus
 CD5ENSG00000110448Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001190  SRCR domain
 IPR003566  T-cell surface glycoprotein CD5
 IPR017448  SRCR-like domain
 IPR036772  SRCR-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0031295 T cell costimulation IDA
 biological_processGO:0097190 apoptotic signaling pathway IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Catsper3tm1.1(KOMP)Vlcg/Catsper3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Catsper3tm1.1(KOMP)Vlcg/Ucd

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Catsper3tm1.1(KOMP)Vlcg/Catsper3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Catsper3tm1.1(KOMP)Vlcg/Ucd

 MP:0001102 small superior vagus ganglion "reduced size of the upper ganglion of the vagus nerve located at the jugular foramen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Catsper3tm1.1(KOMP)Vlcg/Catsper3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Catsper3tm1.1(KOMP)Vlcg/Ucd

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Catsper3tm1.1(KOMP)Vlcg/Catsper3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Catsper3tm1.1(KOMP)Vlcg/Ucd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp7atm1.1Mjp/Atp7a+,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp7atm1.1Mjp/Atp7a+,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

Allelic Composition: Cd5tm1.1Chra/Cd5tm1.1Chra
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp7atm1.1Mjp/Atp7a+,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

 MP:0005002 abnormal T cell clonal deletion "a defect in the process of removal of immature T lymphocytes that interact with self antigens during maturation" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gja1tm1.1Gfi/Gja1tm1.1Gfi
Genetic Background: Not Specified

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Cd5tm1Cgn/Cd5+
Genetic Background: either: (involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/1 * LP)

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Cd5tm1Cgn/Cd5tm1Cgn
Genetic Background: either: (involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/1 * LP)

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp7atm1.1Mjp/Atp7a+,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Atp7atm1.1Mjp/Atp7a+,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Atp7atm1.1Mjp/Atp7a+,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Atp7atm1.1Mjp/Atp7a+,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

Allelic Composition: Cd5tm1.1Chra/Cd5tm1.1Chra,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atp7atm1.1Mjp/Atp7a+,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

Allelic Composition: Cd5tm1.1Chra/Cd5tm1.1Chra
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Cd5tm1Cgn/Cd5tm1Cgn
Genetic Background: either: (involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/1 * LP)

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd5tm1.1Chra/Cd5tm1.1Chra
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Cd5tm1Cgn/Cd5tm1Cgn
Genetic Background: either: (involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/1 * LP)

 MP:0008087 decreased T helper 1 cell number "reduced number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd5tm1.1Chra/Cd5tm1.1Chra,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd5tm1.1Chra/Cd5tm1.1Chra
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Cd5tm1.1Chra/Cd5tm1.1Chra,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Cd5tm1.1Chra/Cd5tm1.1Chra,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Cd5tm1.1Chra/Cd5tm1.1Chra,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Cd5tm1.1Chra/Cd5tm1.1Chra,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Cd5tm1.1Chra/Cd5tm1.1Chra,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0008747 abnormal T cell anergy "any anomaly in the process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction" [GO:0002870]
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Allelic Composition: Atp7atm1.1Mjp/Atp7a+,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

Allelic Composition: Cd5tm1.1Chra/Cd5tm1.1Chra
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0010220 decreased T-helper 17 cell number "reduced number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
Show

Allelic Composition: Cd5tm1.1Chra/Cd5tm1.1Chra
Genetic Background: involves: C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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