ENSMUSG00000024712


Mus musculus

Features
Gene ID: ENSMUSG00000024712
  
Biological name :Rfk
  
Synonyms : Q8CFV9 / Rfk / Riboflavin kinase
  
Possible biological names infered from orthology : Q969G6
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: B
Gene start: 17394043
Gene end: 17401349
  
Corresponding Affymetrix probe sets: 10461898 (MoGene1.0st)   10339794 (MoGene1.0st)   10340094 (MoGene1.0st)   10340155 (MoGene1.0st)   10340318 (MoGene1.0st)   10341155 (MoGene1.0st)   10341443 (MoGene1.0st)   10342294 (MoGene1.0st)   10342349 (MoGene1.0st)   10342442 (MoGene1.0st)   10342738 (MoGene1.0st)   10344083 (MoGene1.0st)   10344216 (MoGene1.0st)   10339005 (MoGene1.0st)   1415737_at (Mouse Genome 430 2.0 Array)   1416229_at (Mouse Genome 430 2.0 Array)   1416230_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025617
NCBI entrez gene - 54391     See in Manteia.
MGI - MGI:1914688
RefSeq - NM_019437
RefSeq Peptide - NP_062310
swissprot - Q8CFV9
Ensembl - ENSMUSG00000024712
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rfkENSDARG00000060522Danio rerio
 ENSGALG00000033558Gallus gallus
 RFKLENSGALG00000000004Gallus gallus
 RFKENSG00000135002Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015865  Riboflavin kinase domain, bacterial/eukaryotic
 IPR023465  Riboflavin kinase domain superfamily
 IPR023468  Riboflavin kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0009231 riboflavin biosynthetic process IEA
 biological_processGO:0009398 FMN biosynthetic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0033864 positive regulation of NAD(P)H oxidase activity IEA
 biological_processGO:0072593 reactive oxygen species metabolic process IGI
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008531 riboflavin kinase activity ISA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Vitamin B2 (riboflavin) metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011077 decreased macrophage nitric oxide production "reduced production of macrophage-derived nitric oxide due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grik4tm1(cre)Mim/Grik4+,Grin1tm1Mim/Grin1tm1Mim
Genetic Background: involves: C57BL/6N

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Grik4tm1(cre)Mim/Grik4+,Grin1tm1Mim/Grin1tm1Mim
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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