ENSMUSG00000024899


Mus musculus

Features
Gene ID: ENSMUSG00000024899
  
Biological name :Papss2
  
Synonyms : Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 2 Sulfate adenylyltransferase Adenylyl-sulfate kinase / O88428 / Papss2
  
Possible biological names infered from orthology : 3-phosphoadenosine 5-phosphosulfate synthase 2 / O95340
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C1
Gene start: 32620005
Gene end: 32667187
  
Corresponding Affymetrix probe sets: 10462507 (MoGene1.0st)   1421987_at (Mouse Genome 430 2.0 Array)   1421988_at (Mouse Genome 430 2.0 Array)   1421989_s_at (Mouse Genome 430 2.0 Array)   1434510_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025833
NCBI entrez gene - 23972     See in Manteia.
MGI - MGI:1330223
RefSeq - XM_006527065
RefSeq - NM_001201470
RefSeq - NM_011864
RefSeq - XM_006527064
RefSeq Peptide - NP_001188399
RefSeq Peptide - NP_035994
swissprot - O88428
Ensembl - ENSMUSG00000024899
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 papss2aENSDARG00000071021Danio rerio
 papss2bENSDARG00000056600Danio rerio
 PAPSS2ENSGALG00000003689Gallus gallus
 O95340ENSG00000198682Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Papss1 / Q60967 / Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1 Sulfate adenylyltransferase Adenylyl-sulfate kinase / O43252* / 3-phosphoadenosine 5-phosphosulfate synthase 1*ENSMUSG0000002803273


Protein motifs (from Interpro)
Interpro ID Name
 IPR002650  Sulphate adenylyltransferase
 IPR002891  Adenylyl-sulfate kinase
 IPR014729  Rossmann-like alpha/beta/alpha sandwich fold
 IPR015947  PUA-like superfamily
 IPR024951  Sulphate adenylyltransferase catalytic domain
 IPR025980  ATP-sulfurylase PUA-like domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000103 sulfate assimilation IDA
 biological_processGO:0007596 blood coagulation IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0050428 3"-phosphoadenosine 5"-phosphosulfate biosynthetic process IBA
 biological_processGO:0060348 bone development IMP
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004020 adenylylsulfate kinase activity IDA
 molecular_functionGO:0004781 sulfate adenylyltransferase (ATP) activity IDA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity ISS


Pathways (from Reactome)
Pathway description
Transport and synthesis of PAPS


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000071 axial skeleton hypoplasia "reduced cell number in the skeletal elements of the trunk" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:55583]
Show

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000120 malocclusion "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]
Show

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: involves: C57BL/6J * LDJ/Le

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000435 shortened head "reduced anterior-posterior length of the head" [J:42035]
Show

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

 MP:0000440 domed skull 
Show

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: involves: C57BL/6J * LDJ/Le

 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
Show

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

 MP:0000588 thick tail "a tail with a greater diameter than the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
Show

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001259 abnormal body weight "anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Epotm1Knni/Epotm1Knni,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ikbkbtm1Lex/Ikbkbtm1Lex,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEvBrd

 MP:0002657 chondrodystrophy "abnormal development of the cartilage primordia of long bones, resulting in abnormally short extremities but normal head and trunk" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002993 arthritis "joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: involves: C57BL/6J * LDJ/Le

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: B6C3Fe a/a-Papss2bm/J

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: involves: C57BL/6J * LDJ/Le

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: involves: LDJ/LeJ

 MP:0003409 decreased width of hypertrophic chondrocyte zone "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: involves: C57BL/6J * LDJ/Le

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
Show

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: B6C3Fe a/a-Papss2bm/J

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: involves: C57BL/6J * LDJ/Le

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: involves: LDJ/LeJ

 MP:0004321 short sternum "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

 MP:0004340 short scapula "reduced length of either or both of the large, flat bones of the back part of the shoulder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

 MP:0004355 short radius "reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

 MP:0004672 short ribs "reduced length of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Tusc2tm1Avi/Tusc2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: involves: C57BL/6J * LDJ/Le

 MP:0006397 disorganized long bone epiphyseal plate "a lack of the regular arrangement of the cells or zones of the epiphyseal plate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: involves: LDJ/LeJ

 MP:0008272 abnormal endochondral bone ossification "anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]
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Allelic Composition: Papss2bm/Papss2bm
Genetic Background: B6C3Fe a/a-Papss2bm/J

 MP:0008525 decreased skull height "decrease in the distance between the cranial base and the upper domelike portion of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Eya1tm1Rilm/Eya1+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009780 abnormal chondrocyte physiology "any functional anomaly of nondividing cartilage cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Papss2bm/Papss2bm
Genetic Background: involves: LDJ/LeJ

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Impad1Gt(RST634)Byg/Impad1Gt(RST634)Byg,Papss2bm/Papss2bm
Genetic Background: involves: 129P2/OlaHsd * LDJ/Le

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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