ENSMUSG00000024979


Mus musculus

Features
Gene ID: ENSMUSG00000024979
  
Biological name :Tectb
  
Synonyms : O08524 / Tectb / tectorin beta
  
Possible biological names infered from orthology : Q96PL2
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: D2
Gene start: 55180733
Gene end: 55196313
  
Corresponding Affymetrix probe sets: 10464034 (MoGene1.0st)   1430912_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121767
Ensembl peptide - ENSMUSP00000025936
Ensembl peptide - ENSMUSP00000113805
Ensembl peptide - ENSMUSP00000117645
NCBI entrez gene - 21684     See in Manteia.
MGI - MGI:109574
RefSeq - XM_006526903
RefSeq - NM_009348
RefSeq - XM_006526902
RefSeq Peptide - NP_033374
swissprot - D3Z273
swissprot - O08524
swissprot - Q1HL20
swissprot - F6Z818
swissprot - D3Z3Y6
Ensembl - ENSMUSG00000024979
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tectbENSDARG00000045268Danio rerio
 TECTBENSGALG00000008802Gallus gallus
 TECTBENSG00000119913Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zpld1 / Q8BGZ8 / zona pellucida like domain containing 1 / Q8TCW7*ENSMUSG0000006431026


Protein motifs (from Interpro)
Interpro ID Name
 IPR001507  Zona pellucida domain
 IPR017977  Zona pellucida domain, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007605 sensory perception of sound TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 molecular_functionGO:0005201 extracellular matrix structural constituent TAS


Pathways (from Reactome)
Pathway description
Post-translational modification: synthesis of GPI-anchored proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003149 abnormal tectorial membrane morphology "malformation, malfunction or absence of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells; sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair cell membrane potential, transducing sound into electrical signals" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:77634]
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Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004417 decreased cochlear nerve compound action potential "reduction of the combined potentials resulting from activation of the auditory division of the eighth cranial nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004591 enlarged tectorial membrane "increased size of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004736 abnormal distortion product otoacoustic emission "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006384 enhanced cochlear frequency tuning "increase in the sharpness of frequency resolution of the cochlea " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0013962 absent Hensen stripe "absence of the dark, nonstriated, V-shaped band (ridge) that is normally found on the underside of the tectorial membrane (TM) in the basal region of the cochlea, from which fine gelatinous trabeculae extend to fix the TM to the border cells, i.e. cells directly adjacent to the inner phalangeal cells" [ISBN:3662026767, PMID:25080593]
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Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0014089 abnormal tectorial membrane marginal band morphology "any structural anomaly of the dense thickening of the lateral edge of the tectorial membrane" [PMID:18797289, PMID:24363064]
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Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0014091 abnormal tectorial membrane striated-sheet matrix morphology "any structural anomaly of the laminated, striated-sheet matrix within which collagen fibrils of the TM are imbedded; the striated sheet matrix is formed by two types of fine-diameter collagen filaments, a light and a dark staining type that lie in parallel within the plane of each sheet and are extensively linked along their length by staggered cross bridges; it originates medially within the sulcal zone, extends to the marginal band and is particularly evident in apical regions of the cochlea, where it has a less compressed appearance" [PMID:18797289, PMID:24363064]
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Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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