Manteia - Molecule gene

ENSMUSG00000025001

Mus musculus

Features

Gene ID:	ENSMUSG00000025001

Biological name :	Hells

Synonyms :	Hells / Lymphocyte-specific helicase / Q60848

Possible biological names infered from orthology :	helicase, lymphoid specific / Q9NRZ9

Species:	Mus musculus

Chr. number:	19
Strand:	1
Band:	C3
Gene start:	38930915
Gene end:	38971051

Corresponding Affymetrix probe sets:	10462973 (MoGene1.0st) 1417541_at (Mouse Genome 430 2.0 Array) 1430139_at (Mouse Genome 430 2.0 Array) 1453361_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000116710 Ensembl peptide - ENSMUSP00000025965 NCBI entrez gene - 15201 See in Manteia. MGI - MGI:106209 RefSeq - NM_008234 RefSeq - XM_006526699 RefSeq Peptide - NP_032260 swissprot - D3Z414 swissprot - Q60848 Ensembl - ENSMUSG00000025001

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
hells	ENSDARG00000057738	Danio rerio
HELLS	ENSGALG00000005451	Gallus gallus
HELLS	ENSG00000119969	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR000330	SNF2-related, N-terminal domain
IPR001650	Helicase, C-terminal
IPR014001	Helicase superfamily 1/2, ATP-binding domain
IPR027417	P-loop containing nucleoside triphosphate hydrolase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001655	urogenital system development	IMP
biological_process	GO:0006306	DNA methylation	IMP
biological_process	GO:0006342	chromatin silencing	IMP
biological_process	GO:0006346	methylation-dependent chromatin silencing	IMP
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0007049	cell cycle	IEA
biological_process	GO:0007275	multicellular organism development	IMP
biological_process	GO:0010216	maintenance of DNA methylation	IMP
biological_process	GO:0030098	lymphocyte differentiation	TAS
biological_process	GO:0031508	pericentric heterochromatin assembly	IMP
biological_process	GO:0043066	negative regulation of apoptotic process	IMP
biological_process	GO:0046651	lymphocyte proliferation	IEP
biological_process	GO:0051301	cell division	IEA
biological_process	GO:1990830	cellular response to leukemia inhibitory factor	IEP
biological_process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	IMP
cellular_component	GO:0000775	chromosome, centromeric region	IDA
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0005721	pericentric heterochromatin	IDA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0003682	chromatin binding	IDA
molecular_function	GO:0004386	helicase activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016787	hydrolase activity	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000060	delayed bone ossification	"late onset of the formation of bone" [J:40203]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0000066	osteoporosis	"reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0000131	abnormal long bone epiphysis morphology	"the head of a developing long bone that is separated from the shaft by the epiphyseal plate" [J:61509]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0000160	kyphosis	"forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0000183	decreased circulating LDL cholesterol level	"less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Hells^{tm1a(EUCOMM)Wtsi}/Hells^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Hells^{tm1a(EUCOMM)Wtsi}/Ieg
MP:0000189	hypoglycemia	"low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0000334	decreased granulocyte number	"fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Hells^{tm1a(EUCOMM)Wtsi}/Hells^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Hells^{tm1a(EUCOMM)Wtsi}/Ieg
MP:0000352	decreased cell proliferation	"less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0000414	alopecia	"absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0000558	abnormal tibia morphology	"atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0000692	small spleen	"decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tbx5^tm1.1Jse/Tbx5⁺ Genetic Background: involves: Black Swiss
MP:0000706	small thymus	"reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]	Show Allelic Composition: Tbx5^tm1.1Jse/Tbx5⁺ Genetic Background: involves: Black Swiss Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0001177	atelectasis	"collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0001242	hyperkeratosis	"increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Tbx5^tm1.1Jse/Tbx5⁺ Genetic Background: involves: Black Swiss Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Hells^{tm1a(EUCOMM)Wtsi}/Hells^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Hells^{tm1a(EUCOMM)Wtsi}/Ieg
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Hells^{tm1a(EUCOMM)Wtsi}/Hells^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Hells^{tm1a(EUCOMM)Wtsi}/Ieg
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0001953	respiratory failure	"cessation of or failure to commence breathing" [MGI:cls, J:60159]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0002075	abnormal coat color	"irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mfge8^{Gt(KST227)Byg}/Mfge8^{Gt(KST227)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002114	abnormal axial skeleton morphology	"abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tbx5^tm1.1Jse/Tbx5⁺ Genetic Background: involves: Black Swiss Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0002644	decreased circulating triglyceride level	"lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Hells^{tm1a(EUCOMM)Wtsi}/Hells^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Hells^{tm1a(EUCOMM)Wtsi}/Ieg
MP:0002703	abnormal renal tubules	"anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0002705	dilated renal tubules	"enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tbx5^tm1.1Jse/Tbx5⁺ Genetic Background: involves: Black Swiss Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0002764	short tibia	" reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0002989	small kidney	"reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0003047	abnormal thoracic vertebrae morphology	"malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0003109	short femur	"reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0003123	paternal imprinting	"specific loci are inactivated during spermatogenesis and are not expressed in offspring " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator, llw2:Linda Washburn, Mouse Genome Informatics Curator]	Show Allelic Composition: Abca1^tm1.1Jp/Abca1^tm1.1Jp Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0003207	decreased sensitivity to gamma-irradiation	"decreased incidence of cell death following high levels of gamma-irradiation" [J:92917, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0003419	delayed endochondral bone ossification	"late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0003702	abnormal chromosome morphology	"anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Tbx5^tm1.1Jse/Tbx5⁺ Genetic Background: involves: Black Swiss
MP:0003723	abnormal long bone morphology	"malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0003786	premature aging	"earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0004023	abnormal chromosome number	"chromosome count is other than the expected diploid chromosome number" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0004153	increased renal tubule apoptosis	"increase in the number of renal tubule cells undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Tbx5^tm1.1Jse/Tbx5⁺ Genetic Background: involves: Black Swiss
MP:0004154	renal tubular necrosis	"pathological cell death in the proximal and/or distal renal tubules, usually due to irreversible damage " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Tbx5^tm1.1Jse/Tbx5⁺ Genetic Background: involves: Black Swiss
MP:0004756	abnormal proximal convoluted tubule morphology	"any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tbx5^tm1.1Jse/Tbx5⁺ Genetic Background: involves: Black Swiss
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tbx5^tm1.1Jse/Tbx5⁺ Genetic Background: involves: Black Swiss
MP:0005090	increased double-negative T cells count	"greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Tbx5^tm1.1Jse/Tbx5⁺ Genetic Background: involves: Black Swiss
MP:0005150	cachexia	"general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0005179	decreased total circulating cholesterol level	"less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Hells^{tm1a(EUCOMM)Wtsi}/Hells^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Hells^{tm1a(EUCOMM)Wtsi}/Ieg
MP:0008078	increased CD8-positive T cell number	"greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tbx5^tm1.1Jse/Tbx5⁺ Genetic Background: involves: Black Swiss
MP:0008495	decreased IgG1 level	"less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hells^{tm1a(EUCOMM)Wtsi}/Hells^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Hells^{tm1a(EUCOMM)Wtsi}/Ieg
MP:0008844	decreased subcutaneous adipose tissue amount	"reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0009429	decreased embryo weight	"reduced weight of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0009431	decreased fetal weight	"reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0009674	decreased birth weight	"reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Tbx5^tm1.1Jse/Tbx5⁺ Genetic Background: involves: Black Swiss
MP:0011090	partial perinatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Hells^tm1Rarc/Hells^tm1Rarc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H
MP:0013675	decreased Ly6C-positive mature NK cell number	"reduction in the number of mature NK cells expressing the memory marker Ly6C" [MGI:Saran]	Show Allelic Composition: Gtpbp2^{tm1b(KOMP)Mbp}/Gtpbp2⁺ Genetic Background: C57BL/6N-Gtpbp2^{tm1b(KOMP)Mbp}/Ucd

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr