ENSMUSG00000025220


Mus musculus

Features
Gene ID: ENSMUSG00000025220
  
Biological name :Mgea5
  
Synonyms : Mgea5 / Protein O-GlcNAcase / Q9EQQ9
  
Possible biological names infered from orthology : meningioma expressed antigen 5 (hyaluronidase) / O60502
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C3
Gene start: 45750261
Gene end: 45783520
  
Corresponding Affymetrix probe sets: 10468089 (MoGene1.0st)   1422900_at (Mouse Genome 430 2.0 Array)   1422901_at (Mouse Genome 430 2.0 Array)   1422902_s_at (Mouse Genome 430 2.0 Array)   1433654_at (Mouse Genome 430 2.0 Array)   1437129_at (Mouse Genome 430 2.0 Array)   1439081_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026243
NCBI entrez gene - 76055     See in Manteia.
MGI - MGI:1932139
RefSeq - NM_023799
RefSeq Peptide - NP_076288
swissprot - Q9EQQ9
Ensembl - ENSMUSG00000025220
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mgea5ENSDARG00000074686Danio rerio
 MGEA5ENSGALG00000007697Gallus gallus
 MGEA5ENSG00000198408Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011496  Beta-N-acetylglucosaminidase
 IPR016181  Acyl-CoA N-acyltransferase
 IPR017853  Glycoside hydrolase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006044 N-acetylglucosamine metabolic process IEA
 biological_processGO:0006517 protein deglycosylation IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009100 glycoprotein metabolic process IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016231 beta-N-acetylglucosaminidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0102166 [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity IEA
 molecular_functionGO:0102167 [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity IEA
 molecular_functionGO:0102571 [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sohlh2tm1Fkh/Sohlh2tm1Fkh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Sohlh2tm1Fkh/Sohlh2tm1Fkh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sohlh2tm1Fkh/Sohlh2tm1Fkh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sohlh2tm1Fkh/Sohlh2tm1Fkh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sohlh2tm1Fkh/Sohlh2tm1Fkh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Sohlh2tm1Fkh/Sohlh2tm1Fkh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sohlh2tm1Fkh/Sohlh2tm1Fkh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Sohlh2tm1Fkh/Sohlh2tm1Fkh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0010865 prenatal growth retardation "slow or limited development during the prenatal period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sohlh2tm1Fkh/Sohlh2tm1Fkh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Sohlh2tm1Fkh/Sohlh2tm1Fkh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Sohlh2tm1Fkh/Sohlh2tm1Fkh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0013289 abnormal mitotic cytokinesis "any anomaly in the process that results in the division of the cytoplasm of a cell after mitosis, this process consists of two distinct processes furrowing and abscission" [GO:0000281, MGI:smb]
Show

Allelic Composition: Sohlh2tm1Fkh/Sohlh2tm1Fkh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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