ENSMUSG00000025283


Mus musculus

Features
Gene ID: ENSMUSG00000025283
  
Biological name :Sat1
  
Synonyms : P48026 / Sat1 / spermidine/spermine N1-acetyl transferase 1
  
Possible biological names infered from orthology : P21673 / spermidine/spermine N1-acetyltransferase 1
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: F3
Gene start: 155213132
Gene end: 155216449
  
Corresponding Affymetrix probe sets: 10607467 (MoGene1.0st)   1420502_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026318
Ensembl peptide - ENSMUSP00000108170
Ensembl peptide - ENSMUSP00000138776
NCBI entrez gene - 20229     See in Manteia.
MGI - MGI:98233
RefSeq - NM_001291865
RefSeq - NM_009121
RefSeq Peptide - NP_001278794
RefSeq Peptide - NP_033147
swissprot - S4R2T2
swissprot - P48026
swissprot - A2BES2
Ensembl - ENSMUSG00000025283
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SAT1ENSGALG00000016348Gallus gallus
 SAT1ENSG00000130066Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Satl1 / Q9D5N8 / Spermidine/spermine N(1)-acetyltransferase-like protein 1 / Q86VE3* / spermidine/spermine N1-acetyl transferase like 1*ENSMUSG0000002552755
Sat2 / Q6P8J2 / Mus musculus spermidine/spermine N1-acetyl transferase 2 (Sat2), transcript variant 2, mRNA. / Q96F10* / spermidine/spermine N1-acetyltransferase family member 2*ENSMUSG0000006983544


Protein motifs (from Interpro)
Interpro ID Name
 IPR000182  GNAT domain
 IPR016181  Acyl-CoA N-acyltransferase
 IPR032957  Diamine acetyltransferase 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006595 polyamine metabolic process IEA
 biological_processGO:0006598 polyamine catabolic process IEA
 biological_processGO:0009447 putrescine catabolic process IEA
 biological_processGO:0032918 spermidine acetylation IEA
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0046208 spermine catabolic process TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004145 diamine N-acetyltransferase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008080 N-acetyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0019809 spermidine binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Interconversion of polyamines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Notch1tm3(cre)Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Notch1tm3(cre)Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch1tm3(cre)Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm3(cre)Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
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Allelic Composition: Notch1tm3(cre)Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch1tm3(cre)Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Notch1tm3(cre)Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0005670 abnormal white fat physiology "functional aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Notch1tm3(cre)Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0008908 increased total fat pad weight "greater than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm3(cre)Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0010957 abnormal aerobic respiration "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060]
Show

Allelic Composition: Notch1tm3(cre)Rko/Notch1tm3(cre)Rko
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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