ENSMUSG00000025318


Mus musculus

Features
Gene ID: ENSMUSG00000025318
  
Biological name :Jph3
  
Synonyms : Jph3 / Junctophilin-3 / Q9ET77
  
Possible biological names infered from orthology : Q8WXH2
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E1
Gene start: 121729623
Gene end: 121794276
  
Corresponding Affymetrix probe sets: 10576062 (MoGene1.0st)   1418161_at (Mouse Genome 430 2.0 Array)   1443724_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026357
Ensembl peptide - ENSMUSP00000126190
NCBI entrez gene - 57340     See in Manteia.
MGI - MGI:1891497
RefSeq - NM_020605
RefSeq Peptide - NP_065630
swissprot - Q9ET77
Ensembl - ENSMUSG00000025318
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 jph3ENSDARG00000102204Danio rerio
 si:ch211-146m13.3ENSDARG00000059534Danio rerio
 JPH3ENSGALG00000029424Gallus gallus
 JPH3ENSG00000154118Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Jph1 / Q9ET80 / Junctophilin-1 / Q9HDC5*ENSMUSG0000004268645
Jph2 / Q9ET78 / Junctophilin-2 / Q9BR39*ENSMUSG0000001781742
Jph4 / Q80WT0 / Junctophilin-4 / Q96JJ6*ENSMUSG0000002220833


Protein motifs (from Interpro)
Interpro ID Name
 IPR003409  MORN motif
 IPR017191  Junctophilin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007612 learning IGI
 biological_processGO:0007613 memory IMP
 biological_processGO:0035640 exploration behavior IMP
 biological_processGO:0040011 locomotion IMP
 biological_processGO:0048168 regulation of neuronal synaptic plasticity IMP
 biological_processGO:0050885 neuromuscular process controlling balance IGI
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 biological_processGO:0060314 regulation of ryanodine-sensitive calcium-release channel activity IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 cellular_componentGO:0030314 junctional membrane complex IEA
 molecular_functionGO:0015278 calcium-release channel activity IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Htr2atm1Grch/Htr2atm2Grch,Slc6a4tm1(cre)Grch/Slc6a4+
Genetic Background: involves: 129S6/SvEvTac

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Htr2atm1Grch/Htr2atm2Grch,Slc6a4tm1(cre)Grch/Slc6a4+
Genetic Background: involves: 129S6/SvEvTac

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgf2tm2Doe/Fgf2tm2Doe
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
Show

Allelic Composition: Htr2atm1Grch/Htr2atm2Grch,Slc6a4tm1(cre)Grch/Slc6a4+
Genetic Background: involves: 129S6/SvEvTac

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Htr2atm1Grch/Htr2atm2Grch,Slc6a4tm1(cre)Grch/Slc6a4+
Genetic Background: involves: 129S6/SvEvTac

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htr2atm1Grch/Htr2atm2Grch,Slc6a4tm1(cre)Grch/Slc6a4+
Genetic Background: involves: 129S6/SvEvTac

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Htr2atm1Grch/Htr2atm2Grch,Slc6a4tm1(cre)Grch/Slc6a4+
Genetic Background: involves: 129S6/SvEvTac

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htr2atm1Grch/Htr2atm2Grch,Slc6a4tm1(cre)Grch/Slc6a4+
Genetic Background: involves: 129S6/SvEvTac

 MP:0002799 abnormal passive avoidance behavior "defects in the ability of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously with prolonged latency" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Htr2atm1Grch/Htr2atm2Grch,Slc6a4tm1(cre)Grch/Slc6a4+
Genetic Background: involves: 129S6/SvEvTac

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Htr2atm1Grch/Htr2atm2Grch,Slc6a4tm1(cre)Grch/Slc6a4+
Genetic Background: involves: 129S6/SvEvTac

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Htr2atm1Grch/Htr2atm2Grch,Slc6a4tm1(cre)Grch/Slc6a4+
Genetic Background: involves: 129S6/SvEvTac

 MP:0003412 abnormal afterhyperpolarization "anomaly in the currents that follow an action potential and influence firing frequency and neuronal integration" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94941]
Show

Allelic Composition: Htr2atm1Grch/Htr2atm2Grch,Slc6a4tm1(cre)Grch/Slc6a4+
Genetic Background: involves: 129S6/SvEvTac

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Htr2atm1Grch/Htr2atm2Grch,Slc6a4tm1(cre)Grch/Slc6a4+
Genetic Background: involves: 129S6/SvEvTac

 MP:0011084 partial lethality at weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [MGI:csmith]
Show

Allelic Composition: Htr2atm1Grch/Htr2atm2Grch,Slc6a4tm1(cre)Grch/Slc6a4+
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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