ENSMUSG00000025374


Mus musculus

Features
Gene ID: ENSMUSG00000025374
  
Biological name :Nabp2
  
Synonyms : Nabp2 / Q8R2Y9 / SOSS complex subunit B1
  
Possible biological names infered from orthology : nucleic acid binding protein 2 / Q9BQ15
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D3
Gene start: 128401395
Gene end: 128411492
  
Corresponding Affymetrix probe sets: 10373388 (MoGene1.0st)   1451291_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126842
Ensembl peptide - ENSMUSP00000131171
Ensembl peptide - ENSMUSP00000130608
Ensembl peptide - ENSMUSP00000128634
Ensembl peptide - ENSMUSP00000127605
Ensembl peptide - ENSMUSP00000127436
Ensembl peptide - ENSMUSP00000127015
Ensembl peptide - ENSMUSP00000026439
NCBI entrez gene - 69917     See in Manteia.
MGI - MGI:1917167
RefSeq - XM_017314078
RefSeq - NM_027257
RefSeq - XM_006514066
RefSeq - XM_006514067
RefSeq - XM_006514068
RefSeq Peptide - NP_081533
RefSeq Peptide - NP_001345901
swissprot - Q8R2Y9
swissprot - E9Q1I2
swissprot - E9Q199
swissprot - E9PW70
swissprot - E9Q2V9
swissprot - E9PV68
swissprot - E9Q5F7
Ensembl - ENSMUSG00000025374
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NABP2ENSDARG00000090976Danio rerio
 NABP2ENSGALG00000031958Gallus gallus
 NABP2ENSG00000139579Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nabp1 / Q8BGW5 / SOSS complex subunit B2 / Q96AH0* / nucleic acid binding protein 1*ENSMUSG0000002610752


Protein motifs (from Interpro)
Interpro ID Name
 IPR004365  OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
 IPR012340  Nucleic acid-binding, OB-fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0006281 DNA repair IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007093 mitotic cell cycle checkpoint IEA
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0070200 establishment of protein localization to telomere IEA
 biological_processGO:1904355 positive regulation of telomere capping IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0070876 SOSS complex IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0070182 DNA polymerase binding IEA
 molecular_functionGO:0098505 G-rich strand telomeric DNA binding IEA


Pathways (from Reactome)
Pathway description
RNA polymerase II transcribes snRNA genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000030 abnormal tympanic ring morphology "malformed bony ring at the ear canal to which the tympanic membrane is attached" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: ApcMin/Apc+,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SWR

Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: ApcMin/Apc+,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SWR

Allelic Composition: Nabp2tm1.2Nfel/Nabp2tm1.2Nfel,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N * SJL

Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: ApcMin/Apc+,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SWR

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ApcMin/Apc+,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SWR

Allelic Composition: Nabp2tm1.2Nfel/Nabp2tm1.2Nfel,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N * SJL

 MP:0000443 abnormal snout morphology "anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0000460 mandible hypoplasia "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: ApcMin/Apc+,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SWR

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

Allelic Composition: Nabp2tm1.1Schg/Nabp2tm1.1Schg
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: ApcMin/Apc+,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SWR

Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Nox4tm1Kkr/Nox4tm1Kkr
Genetic Background: B6.129-Nox4tm1Kkr

 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
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Allelic Composition: Ffar2tm2Soff/Ffar2tm2Soff,Ffar3tm2.1Soff/Ffar3tm2.1Soff,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ffar2tm2Soff/Ffar2tm2Soff,Ffar3tm2.1Soff/Ffar3tm2.1Soff,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0002275 abnormal type II pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0002820 abnormal premaxilla morphology "malformation or absence of the anterior and inner portion of the maxilla" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:76662]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0002823 abnormal rib development "anomalous formation of the bones forming the bony wall of the chest" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84754]
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Allelic Composition: ApcMin/Apc+,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SWR

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0003795 abnormal bone structure 
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Allelic Composition: ApcMin/Apc+,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SWR

 MP:0003992 increased mortality induced by ionizing radiation "greater sensitivity to doses of ionizing radiation that include ultraviolet light, X-rays, or gamma rays" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SWR

 MP:0004227 increased cellular sensitivity to ionizing radiation "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0004340 short scapula "reduced length of either or both of the large, flat bones of the back part of the shoulder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0004347 abnormal scapular spine morphology "any structural anomaly of the trianguar ridge on the dorsal aspect of the scapula which separates the supra- from the infraspinatous fossa and where the trapezius and deltoid muscles are attached " [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: ApcMin/Apc+,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SWR

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0004353 abnormal deltoid tuberosity morphology "any structural anomaly of a rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: ApcMin/Apc+,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SWR

 MP:0004354 absent deltoid tuberosity "missing the rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: ApcMin/Apc+,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SWR

 MP:0004355 short radius "reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nabp2tm1.2Nfel/Nabp2tm1.2Nfel,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N * SJL

Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0004625 abnormal rib attachment "any anomaly in the in the normal joining of the ribs to the vertebral column or to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0005430 absent fibula "missing the lateral and shorter of the two bones of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86196]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: ApcMin/Apc+,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SWR

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SWR

Allelic Composition: Nabp2tm1.2Nfel/Nabp2tm1.2Nfel,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N * SJL

Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ffar2tm2Soff/Ffar2tm2Soff,Ffar3tm2.1Soff/Ffar3tm2.1Soff,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
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Allelic Composition: ApcMin/Apc+,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SWR

Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Nabp2tm1Schg/Nabp2tm1Schg
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nabp2tm1.1Schg/Nabp2tm1.1Schg
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

Allelic Composition: Nabp2tm1.1Schg/Nabp2tm1.1Schg
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010099 abnormal thoracic cage shape "anomaly in the overall regular dome shape of the ribcage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0010103 small thoracic cage "reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SWR

Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0010207 abnormal telomere morphology "any structural anomaly of the terminal repetitive DNA section of a chromosome which is involved in chromosomal replication and senescence, and which protects the end of the chromosome from deterioration" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nabp2tm1.1Schg/Nabp2tm1.1Schg
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010819 primary atelectasis "nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SWR

 MP:0010903 abnormal pulmonary alveolus wall morphology 
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Nabp2tm1.2Nfel/Nabp2tm1.2Nfel,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

Allelic Composition: Nabp2tm1.1Schg/Nabp2tm1.1Schg
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: ApcMin/Apc+,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SWR

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Nabp2tm1Schg/Nabp2tm1Schg
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: ApcMin/Apc+,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SWR

 MP:0013600 testis degeneration "a retrogressive impairment of function or destruction of either or both of the male reproductive glands" [MGI:Anna]
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Allelic Composition: Nabp2tm1.1Kkha/Nabp2tm1.1Kkha,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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