ENSMUSG00000025402


Mus musculus

Features
Gene ID: ENSMUSG00000025402
  
Biological name :Nab2
  
Synonyms : Nab2 / NGFI-A-binding protein 2 / Q61127
  
Possible biological names infered from orthology : Q15742
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D3
Gene start: 127660918
Gene end: 127668568
  
Corresponding Affymetrix probe sets: 10373313 (MoGene1.0st)   1417930_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118036
Ensembl peptide - ENSMUSP00000121737
Ensembl peptide - ENSMUSP00000026469
Ensembl peptide - ENSMUSP00000096761
NCBI entrez gene - 17937     See in Manteia.
MGI - MGI:107563
RefSeq - NM_001122895
RefSeq - NM_008668
RefSeq Peptide - NP_001116367
RefSeq Peptide - NP_032694
swissprot - Q61127
swissprot - D3Z008
swissprot - Q3TYF1
swissprot - D3Z292
Ensembl - ENSMUSG00000025402
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nab2ENSDARG00000078076Danio rerio
 NAB2ENSGALG00000035028Gallus gallus
 NAB2ENSG00000166886Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nab1 / Q61122 / NGFI-A-binding protein 1 / Q13506*ENSMUSG0000000288138


Protein motifs (from Interpro)
Interpro ID Name
 IPR006988  Nab, N-terminal
 IPR006989  NAB co-repressor, domain
 IPR013761  Sterile alpha motif/pointed domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001958 endochondral ossification IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IGI
 biological_processGO:0014037 Schwann cell differentiation IGI
 biological_processGO:0016480 negative regulation of transcription by RNA polymerase III IEA
 biological_processGO:0042552 myelination IGI
 biological_processGO:0045682 regulation of epidermis development IGI
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:1902949 positive regulation of tau-protein kinase activity IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0008134 transcription factor binding IDA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Pax7tm2Pgr/Pax7tm2Pgr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Pax7tm2Pgr/Pax7tm2Pgr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Myh1tm1b(KOMP)Wtsi/Myh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Myh1tm1b(KOMP)Wtsi/J

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pax7tm2Pgr/Pax7tm2Pgr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Pax7tm2Pgr/Pax7tm2Pgr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax7tm2Pgr/Pax7tm2Pgr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

 MP:0001106 abnormal Schwann cell "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pax7tm2Pgr/Pax7tm2Pgr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

 MP:0001200 thick skin "greater depth of skin " [J:47225]
Show

Allelic Composition: Pax7tm2Pgr/Pax7tm2Pgr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Pax7tm2Pgr/Pax7tm2Pgr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Pax7tm2Pgr/Pax7tm2Pgr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myh1tm1b(KOMP)Wtsi/Myh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Myh1tm1b(KOMP)Wtsi/J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Pax7tm2Pgr/Pax7tm2Pgr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myh1tm1b(KOMP)Wtsi/Myh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Myh1tm1b(KOMP)Wtsi/J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Myh1tm1b(KOMP)Wtsi/Myh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Myh1tm1b(KOMP)Wtsi/J

 MP:0001401 jumpy "marked by fitful, jerky movements" [J:22295]
Show

Allelic Composition: Myh1tm1b(KOMP)Wtsi/Myh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Myh1tm1b(KOMP)Wtsi/J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pax7tm2Pgr/Pax7tm2Pgr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Pax7tm2Pgr/Pax7tm2Pgr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax7tm2Pgr/Pax7tm2Pgr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myh1tm1b(KOMP)Wtsi/Myh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Myh1tm1b(KOMP)Wtsi/J

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax7tm2Pgr/Pax7tm2Pgr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Pax7tm2Pgr/Pax7tm2Pgr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

 MP:0011906 increased Schwann cell proliferation "increase in the expansion rate of a Schwann cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Pax7tm2Pgr/Pax7tm2Pgr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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