ENSMUSG00000025759


Mus musculus

Features
Gene ID: ENSMUSG00000025759
  
Biological name :Mfsd8
  
Synonyms : Major facilitator superfamily domain-containing protein 8 / Mfsd8 / Q8BH31
  
Possible biological names infered from orthology : major facilitator superfamily domain containing 8 / Q8NHS3
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: B
Gene start: 40818103
Gene end: 40846886
  
Corresponding Affymetrix probe sets: 10497944 (MoGene1.0st)   1438497_at (Mouse Genome 430 2.0 Array)   1452335_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144842
Ensembl peptide - ENSMUSP00000145458
Ensembl peptide - ENSMUSP00000145129
Ensembl peptide - ENSMUSP00000145074
Ensembl peptide - ENSMUSP00000026859
NCBI entrez gene - 72175     See in Manteia.
MGI - MGI:1919425
RefSeq - XM_006500788
RefSeq - NM_028140
RefSeq Peptide - NP_082416
swissprot - F6R8A9
swissprot - A0A0N4SVE9
swissprot - A0A0N4SWC1
swissprot - Q8BH31
swissprot - A0A0N4SUV8
Ensembl - ENSMUSG00000025759
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mfsd8ENSDARG00000103235Danio rerio
 MFSD8ENSGALG00000010199Gallus gallus
 MFSD8ENSG00000164073Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011701  Major facilitator superfamily
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007040 lysosome organization IMP
 biological_processGO:0010506 regulation of autophagy IMP
 biological_processGO:0048666 neuron development IMP
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Memo1tm1b(EUCOMM)Wtsi/Memo1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Memo1tm1b(EUCOMM)Wtsi/Bay

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Memo1tm1b(EUCOMM)Wtsi/Memo1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Memo1tm1b(EUCOMM)Wtsi/Bay

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Memo1tm1b(EUCOMM)Wtsi/Memo1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Memo1tm1b(EUCOMM)Wtsi/Bay

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Memo1tm1b(EUCOMM)Wtsi/Memo1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Memo1tm1b(EUCOMM)Wtsi/Bay

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0003632 abnormal nervous system morphology 
Show

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0005058 abnormal lysosome morphology "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0006082 CNS inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
Show

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0006243 abnormal pupil dilation reaction to light "the pupil fails to constrict fully when exposed to bright light" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Memo1tm1b(EUCOMM)Wtsi/Memo1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Memo1tm1b(EUCOMM)Wtsi/Bay

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pink1tm1Aub/Pink1tm1Aub,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
Genetic Background: involves: 129S/SvEv * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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