ENSMUSG00000025899


Mus musculus

Features
Gene ID: ENSMUSG00000025899
  
Biological name :Alkbh8
  
Synonyms : Alkbh8 / Alkylated DNA repair 8 / Q80Y20
  
Possible biological names infered from orthology : alkB homolog 8, tRNA methyltransferase / Q96BT7
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A1
Gene start: 3335140
Gene end: 3391154
  
Corresponding Affymetrix probe sets: 10582925 (MoGene1.0st)   1429521_at (Mouse Genome 430 2.0 Array)   1453539_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148347
Ensembl peptide - ENSMUSP00000148653
Ensembl peptide - ENSMUSP00000148467
Ensembl peptide - ENSMUSP00000148438
Ensembl peptide - ENSMUSP00000148380
Ensembl peptide - ENSMUSP00000061511
Ensembl peptide - ENSMUSP00000125996
Ensembl peptide - ENSMUSP00000148274
NCBI entrez gene - 67667     See in Manteia.
MGI - MGI:1914917
RefSeq - XM_006509883
RefSeq - XM_006509882
RefSeq - XM_006509879
RefSeq - NM_026303
RefSeq - XM_006509880
RefSeq - XM_006509881
RefSeq Peptide - NP_080579
swissprot - Q80Y20
swissprot - A0A1D5RLQ8
swissprot - A0A1D5RL93
swissprot - A0A1D5RLF6
swissprot - A0A1D5RLN3
Ensembl - ENSMUSG00000025899
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 alkbh8ENSDARG00000060256Danio rerio
 ALKBH8ENSGALG00000017170Gallus gallus
 ALKBH8ENSG00000137760Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q80WQ4 / 6430573F11Rik / Probable tRNA methyltransferase 9-like protein / Q9P272* / TRMT9B* / tRNA methyltransferase 9B (putative)*ENSMUSG0000003962015


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR013216  Methyltransferase type 11
 IPR015095  Alkylated DNA repair protein AlkB, homologue 8, N-terminal
 IPR027450  Alpha-ketoglutarate-dependent dioxygenase AlkB-like
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase
 IPR032863  Alkylated DNA repair protein alkB homologue 8
 IPR034256  ALKBH8, RNA recognition motif
 IPR035979  RNA-binding domain superfamily
 IPR037151  Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002098 tRNA wobble uridine modification ISO
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0030488 tRNA methylation ISO
 biological_processGO:0032259 methylation IEA
 biological_processGO:0055114 oxidation-reduction process ISO
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0016604 nuclear body ISO
 molecular_functionGO:0000049 tRNA binding IBA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005506 iron ion binding IDA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008198 ferrous iron binding IBA
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0016300 tRNA (uracil) methyltransferase activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apptm3.2Umu/Apptm2Cwe
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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