ENSMUSG00000025937


Mus musculus

Features
Gene ID: ENSMUSG00000025937
  
Biological name :Lactb2
  
Synonyms : Endoribonuclease LACTB2 / Lactb2 / Q99KR3
  
Possible biological names infered from orthology : lactamase beta 2 / Q53H82
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: A3
Gene start: 13623330
Gene end: 13660546
  
Corresponding Affymetrix probe sets: 10353181 (MoGene1.0st)   1425140_at (Mouse Genome 430 2.0 Array)   1425141_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027071
NCBI entrez gene - 212442     See in Manteia.
MGI - MGI:2442551
RefSeq - NM_145381
RefSeq - XM_006495490
RefSeq Peptide - NP_663356
swissprot - Q99KR3
Ensembl - ENSMUSG00000025937
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LACTB2ENSGALG00000038745Gallus gallus
 LACTB2ENSG00000147592Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001279  Metallo-beta-lactamase
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036866  Ribonuclease Z/Hydroxyacylglutathione hydrolase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005759 mitochondrial matrix ISO
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003727 single-stranded RNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004521 endoribonuclease activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster

 MP:0001511 disheveled coat "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster

 MP:0013317 abnormal seminal vesicle development "aberrant or incomplete differentiation of either of the paired sac-like glandular structures situated posterolateral to the urinary bladder in the male and functioning as part of the reproductive system; seminal vesicles develop from the segments of the Wolffian ducts immediately adjacent to the urogenital sinus" [MGI:Anna]
Show

Allelic Composition: Gli1tm2Alj/Gli1+,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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