ENSMUSG00000025940


Mus musculus

Features
Gene ID: ENSMUSG00000025940
  
Biological name :Tmem70
  
Synonyms : Q921N7 / Tmem70 / Transmembrane protein 70, mitochondrial
  
Possible biological names infered from orthology : Q9BUB7 / transmembrane protein 70
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: A3
Gene start: 16665207
Gene end: 16678275
  
Corresponding Affymetrix probe sets: 10344960 (MoGene1.0st)   1424541_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000070497
Ensembl peptide - ENSMUSP00000135483
NCBI entrez gene - 70397     See in Manteia.
MGI - MGI:1915068
RefSeq - NM_026392
RefSeq - NM_027415
RefSeq Peptide - NP_080668
RefSeq Peptide - NP_081691
swissprot - Q921N7
swissprot - A0A0R4J272
Ensembl - ENSMUSG00000025940
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tmem70ENSDARG00000078773Danio rerio
 TMEM70ENSGALG00000033568Gallus gallus
 Q9BUB7ENSG00000175606Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009724  TMEM70 family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0033615 mitochondrial proton-transporting ATP synthase complex assembly ISS
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032592 integral component of mitochondrial membrane ISO
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Casz1Gt(CJ0565)Wtsi/Casz1Gt(CJ0565)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Casz1Gt(CJ0565)Wtsi/Casz1Gt(CJ0565)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Casz1Gt(CJ0565)Wtsi/Casz1Gt(CJ0565)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003794 delayed somite formation "late onset of the induction and/or differentiation of the somites" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:99723]
Show

Allelic Composition: Casz1Gt(CJ0565)Wtsi/Casz1Gt(CJ0565)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Casz1Gt(CJ0565)Wtsi/Casz1Gt(CJ0565)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004188 delayed embryo turning "completion of axial rotation occurs later than in controls but is eventually completed" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
Show

Allelic Composition: Casz1Gt(CJ0565)Wtsi/Casz1Gt(CJ0565)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Casz1Gt(CJ0565)Wtsi/Casz1Gt(CJ0565)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Tmem70tm1a(KOMP)Wtsi/Tmem70tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Casz1Gt(CJ0565)Wtsi/Casz1Gt(CJ0565)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010959 abnormal oxidative phosphorylation "any anomaly in the process of phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain; oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis" [GO:0006119]
Show

Allelic Composition: Casz1Gt(CJ0565)Wtsi/Casz1Gt(CJ0565)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Casz1Gt(CJ0565)Wtsi/Casz1Gt(CJ0565)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tmem70tm1a(KOMP)Wtsi/Tmem70tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0011633 abnormal mitochondrial shape "any anomaly in the characteristic surface outline or contour of a mitochondria" [MGI:csmith]
Show

Allelic Composition: Tmem70tm1a(KOMP)Wtsi/Tmem70tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0011635 abnormal mitochondrial crista morphology "Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061]
Show

Allelic Composition: Tmem70tm1a(KOMP)Wtsi/Tmem70tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0011636 disorganized mitochondrial cristae "derangement of the pattern of the inward folds of the mitochondrial inner membrane" [MGI:csmith]
Show

Allelic Composition: Tmem70tm1a(KOMP)Wtsi/Tmem70tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0012082 delayed heart development "late onset of the induction and/or differentiation of the heart" [MGI:anna]
Show

Allelic Composition: Tmem70tm1a(KOMP)Wtsi/Tmem70tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0012708 delayed rostral neuropore closure "a delay in the fusion of the cephalic neural folds" [MGI:anna]
Show

Allelic Composition: Tmem70tm1a(KOMP)Wtsi/Tmem70tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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