ENSMUSG00000026039


Mus musculus

Features
Gene ID: ENSMUSG00000026039
  
Biological name :Sgol2a
  
Synonyms : Q7TSY8 / Sgol2a / Shugoshin 2
  
Possible biological names infered from orthology : Q562F6 / SGO2
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C1.3
Gene start: 57995971
Gene end: 58025899
  
Corresponding Affymetrix probe sets: 10346365 (MoGene1.0st)   1437370_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027202
NCBI entrez gene - 68549     See in Manteia.
MGI - MGI:1098767
RefSeq - NM_199007
RefSeq Peptide - NP_950172
swissprot - Q7TSY8
Ensembl - ENSMUSG00000026039
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000008803Gallus gallus
 ENSGALG00000029851Gallus gallus
 SGO2ENSG00000163535Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sgo2b / SGO2* / Q562F6* / shugoshin 2*ENSMUSG0000009444381


Protein motifs (from Interpro)
Interpro ID Name
 IPR026706  Shugoshin 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0007140 male meiotic nuclear division IMP
 biological_processGO:0007143 female meiotic nuclear division IMP
 biological_processGO:0008104 protein localization IMP
 biological_processGO:0010789 meiotic sister chromatid cohesion involved in meiosis I IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0051754 meiotic sister chromatid cohesion, centromeric IMP
 biological_processGO:2000711 positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric IMP
 cellular_componentGO:0000775 chromosome, centromeric region ISO
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000779 condensed chromosome, centromeric region IDA
 cellular_componentGO:0000780 condensed nuclear chromosome, centromeric region IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0030892 mitotic cohesin complex ISO
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Myd88tm1Defr/Myd88tm1Defr,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Myd88tm1Defr/Myd88tm1Defr,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Myd88tm1Defr/Myd88tm1Defr,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
Show

Allelic Composition: Myd88tm1Defr/Myd88tm1Defr,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Myd88tm1Defr/Myd88tm1Defr,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myd88tm1Defr/Myd88tm1Defr,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myd88tm1Defr/Myd88tm1Defr,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Myd88tm1Defr/Myd88tm1Defr,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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