ENSMUSG00000026162


Mus musculus

Features
Gene ID: ENSMUSG00000026162
  
Biological name :Nhej1
  
Synonyms : Nhej1 / non-homologous end-joining factor 1
  
Possible biological names infered from orthology : Q9H9Q4
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C4
Gene start: 74967139
Gene end: 75125200
  
Corresponding Affymetrix probe sets: 10355711 (MoGene1.0st)   1425651_at (Mouse Genome 430 2.0 Array)   1429098_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116797
NCBI entrez gene - 75570     See in Manteia.
MGI - MGI:1922820
RefSeq - NM_029342
RefSeq Peptide - NP_083618
swissprot - F7BTP0
Ensembl - ENSMUSG00000026162
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nhej1ENSDARG00000058893Danio rerio
 ENSGALG00000011335Gallus gallus
 NHEJ1ENSG00000187736Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015381  XLF family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006302 double-strand break repair IEA
 cellular_componentGO:0005634 nucleus IEA


Pathways (from Reactome)
Pathway description
Nonhomologous End-Joining (NHEJ)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Nhej1tm1Fwa/Nhej1tm1Fwa,Xrcc5tm1Nus/Xrcc5tm1Nus
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Nhej1tm1Fwa/Nhej1tm1Fwa
Genetic Background: involves: 129/Sv

 MP:0000705 athymia "absence of the primary lymphoid organ" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Nhej1tm1Fwa/Nhej1tm1Fwa,Xrcc5tm1Nus/Xrcc5tm1Nus
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cers1tm1.1Kwi/Cers1tm1.1Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nhej1tm1.1Ics/Nhej1+
Genetic Background: involves: 129 * C57BL/6

 MP:0000726 absent lymphocyte "lack of specific white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Nhej1tm1Fwa/Nhej1tm1Fwa,Xrcc5tm1Nus/Xrcc5tm1Nus
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Nhej1tm1Fwa/Nhej1tm1Fwa
Genetic Background: involves: 129/Sv

 MP:0001824 abnormal thymic involution "premature or late decline in thymic function normally associated with advancing age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
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Allelic Composition: Rad9atm2Lieb/Rad9a+,Tg(KRT5-cre)1Xya/?
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Nhej1tm1Fwa/Nhej1tm1Fwa
Genetic Background: involves: 129/Sv

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nhej1tm1Fwa/Nhej1tm1Fwa,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129/Sv

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nhej1tm1Fwa/Nhej1tm1Fwa,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129/Sv

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nhej1tm1Fwa/Nhej1tm1Fwa
Genetic Background: involves: 129/Sv

 MP:0004029 spontaneous chromosome breakage "chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Rad9atm2Lieb/Rad9a+,Tg(KRT5-cre)1Xya/?
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Nhej1tm1Fwa/Nhej1tm1Fwa
Genetic Background: involves: 129/Sv

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nhej1tm1Fwa/Nhej1tm1Fwa
Genetic Background: involves: 129/Sv

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cers1tm1.1Kwi/Cers1tm1.1Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006283 medulloblastoma "a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin " [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nhej1tm1Fwa/Nhej1tm1Fwa,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129/Sv

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Cers1tm1.1Kwi/Cers1tm1.1Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nhej1tm1.1Ics/Nhej1tm1.1Ics,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Rad9atm2Lieb/Rad9a+,Tg(KRT5-cre)1Xya/?
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nhej1tm1Fwa/Nhej1tm1Fwa
Genetic Background: involves: 129/Sv

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Nhej1tm1Fwa/Nhej1tm1Fwa
Genetic Background: involves: 129/Sv

 MP:0008754 abnormal T cell receptor V(D)J recombination "any anomaly in the process by which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus" [GO:0033153, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cers1tm1.1Kwi/Cers1tm1.1Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nhej1tm1.1Ics/Nhej1tm1.1Ics,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cers1tm1.1Kwi/Cers1tm1.1Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cers1tm1.1Kwi/Cers1tm1.1Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009542 decreased thymocyte apoptosis "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nhej1tm1.1Ics/Nhej1tm1.1Ics,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0012505 increased neural tube apoptosis "increase in the number of cells of the neural tube undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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