MP:0000598 | abnormal liver morphology | "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170] |
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0000601 | small liver | "reduced size of the liver" [J:23170] |
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0001402 | hypoactivity | "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289] |
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0001505 | hunched posture | "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404] |
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0002628 | fatty liver | "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0003333 | liver fibrosis | "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0004756 | abnormal proximal convoluted tubule morphology | "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0005536 | Leydig cell hypoplasia | "reduced numbers of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0006036 | abnormal mitochondrial physiology | |
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0008489 | postnatal slow weight gain | "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0008807 | increased liver iron level | "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0010398 | decreased liver glycogen level | "less than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0010954 | abnormal cellular respiration | "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333] |
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0011630 | increased mitochondria size | "enlarged the cellular organelles responsible for energy production" [MGI:csmith] |
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0013405 | increased circulating lactate level | "greater amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase" [MPD:Molly] |
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Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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