ENSMUSG00000026270


Mus musculus

Features
Gene ID: ENSMUSG00000026270
  
Biological name :Capn10
  
Synonyms : Calpain-10 / Capn10 / Q9ESK3
  
Possible biological names infered from orthology : Q9HC96
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: D
Gene start: 92934376
Gene end: 92947941
  
Corresponding Affymetrix probe sets: 10348682 (MoGene1.0st)   1416265_at (Mouse Genome 430 2.0 Array)   1452959_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112831
Ensembl peptide - ENSMUSP00000141110
Ensembl peptide - ENSMUSP00000122158
Ensembl peptide - ENSMUSP00000027488
NCBI entrez gene - 23830     See in Manteia.
MGI - MGI:1344392
RefSeq - NM_011796
RefSeq Peptide - NP_035926
swissprot - A0A087WSM6
swissprot - D6RGR0
swissprot - Q9CPY2
swissprot - Q9ESK3
Ensembl - ENSMUSG00000026270
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 capn10ENSDARG00000076634Danio rerio
 CAPN10ENSGALG00000034562Gallus gallus
 CAPN10ENSG00000142330Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Capn15 / Q9JLG8 / Mus musculus calpain 15 (Capn15), transcript variant 1, mRNA. / O75808* / calpain 15*ENSMUSG0000003732621
Capn7 / Q9R1S8 / Calpain-7 / Q9Y6W3*ENSMUSG0000002189315


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR001300  Peptidase C2, calpain, catalytic domain
 IPR022682  Peptidase C2, calpain, large subunit, domain III
 IPR022683  Peptidase C2, calpain, domain III
 IPR022684  Peptidase C2, calpain family
 IPR028791  Calpain-10
 IPR033883  Calpain subdomain III
 IPR036213  Calpain large subunit, domain III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IMP
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0032388 positive regulation of intracellular transport IMP
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0046326 positive regulation of glucose import IEA
 biological_processGO:0097050 type B pancreatic cell apoptotic process IEA
 biological_processGO:2000676 positive regulation of type B pancreatic cell apoptotic process IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004198 calcium-dependent cysteine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

Allelic Composition: Adip1SM/J/?,Capn10tm1Chev/Capn10+
Genetic Background: (B6.129-Capn10tm1Chev x SM/J)F1

 MP:0002693 abnormal pancreas physiology "abberrant function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rbl1tm1Htr/Rbl1tm1Htr,Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI * SJL

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

Allelic Composition: Adip1SM/J/?,Capn10tm1Chev/Capn10+
Genetic Background: (B6.129-Capn10tm1Chev x SM/J)F1

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

Allelic Composition: Adip1SM/J/?,Capn10tm1Chev/Capn10+
Genetic Background: (B6.129-Capn10tm1Chev x SM/J)F1

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

Allelic Composition: Adip1SM/J/?,Capn10tm1Chev/Capn10+
Genetic Background: (B6.129-Capn10tm1Chev x SM/J)F1

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

 MP:0008908 increased total fat pad weight "greater than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

 MP:0009292 increased inguinal fat pad weight 
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Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

 MP:0009298 increased mesenteric fat pad weight 
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Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

 MP:0009302 increased renal fat pad weight 
Show

Allelic Composition: Wnt1sw/Wnt1sw
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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