ENSMUSG00000026273


Mus musculus

Features
Gene ID: ENSMUSG00000026273
  
Biological name :Mterf4
  
Synonyms : Mterf4 / Q8BVN4 / Transcription termination factor 4, mitochondrial
  
Possible biological names infered from orthology : mitochondrial transcription termination factor 4 / Q7Z6M4
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: D
Gene start: 93299211
Gene end: 93305915
  
Corresponding Affymetrix probe sets: 10356771 (MoGene1.0st)   1424430_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108564
Ensembl peptide - ENSMUSP00000108566
Ensembl peptide - ENSMUSP00000027492
NCBI entrez gene - 69821     See in Manteia.
MGI - MGI:1918355
RefSeq - NM_178051
RefSeq - NM_001310756
RefSeq Peptide - NP_001297685
RefSeq Peptide - NP_835152
swissprot - Q8BVN4
swissprot - D3Z3A4
swissprot - D3Z3A2
Ensembl - ENSMUSG00000026273
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkeyp-94h10.5ENSDARG00000079124Danio rerio
 MTERF4ENSG00000122085Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003690  Transcription termination factor, mitochondrial/chloroplastic


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0006390 mitochondrial transcription IMP
 biological_processGO:0006626 protein targeting to mitochondrion IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008380 RNA splicing IBA
 biological_processGO:0042255 ribosome assembly IMP
 biological_processGO:0043010 camera-type eye development IMP
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005762 mitochondrial large ribosomal subunit IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003727 single-stranded RNA binding IBA
 molecular_functionGO:0019843 rRNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Gja5tm1Lumi/Gja5+,Irx3tm1Hui/Irx3tm1Hui
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Gja5tm1Lumi/Gja5+,Irx3tm1Hui/Irx3tm1Hui
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gja5tm1Lumi/Gja5+,Irx3tm1Hui/Irx3tm1Hui
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Bcl2tm2.1Lbox/Bcl2tm2.1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gja5tm1Lumi/Gja5+,Irx3tm1Hui/Irx3tm1Hui
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gja5tm1Lumi/Gja5+,Irx3tm1Hui/Irx3tm1Hui
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Gja5tm1Lumi/Gja5+,Irx3tm1Hui/Irx3tm1Hui
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Gja5tm1Lumi/Gja5+,Irx3tm1Hui/Irx3tm1Hui
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Bcl2tm2.1Lbox/Bcl2tm2.1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0011388 absent heart "absence of the hollow, muscular organ that maintains the circulation of the blood" [MGI:smb]
Show

Allelic Composition: Bcl2tm2.1Lbox/Bcl2tm2.1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0011389 absent optic disc "absence of the area in the retina where all of the axons of the ganglion cells exit the retina to form the optic nerve" [MGI:smb]
Show

Allelic Composition: Bcl2tm2.1Lbox/Bcl2tm2.1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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