ENSMUSG00000026385


Mus musculus

Features
Gene ID: ENSMUSG00000026385
  
Biological name :Dbi
  
Synonyms : Dbi / diazepam binding inhibitor / P31786
  
Possible biological names infered from orthology : diazepam binding inhibitor, acyl-CoA binding protein / P07108
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E2.3
Gene start: 120113280
Gene end: 120121078
  
Corresponding Affymetrix probe sets: 10357242 (MoGene1.0st)   1422432_at (Mouse Genome 430 2.0 Array)   1433991_x_at (Mouse Genome 430 2.0 Array)   1438093_x_at (Mouse Genome 430 2.0 Array)   1455976_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138014
Ensembl peptide - ENSMUSP00000027634
Ensembl peptide - ENSMUSP00000108267
Ensembl peptide - ENSMUSP00000114705
NCBI entrez gene - 13167     See in Manteia.
MGI - MGI:94865
RefSeq - NM_001037999
RefSeq - NM_007830
RefSeq Peptide - NP_031856
RefSeq Peptide - NP_001033088
swissprot - M0QWU8
swissprot - Q548W7
swissprot - D3Z563
swissprot - P31786
swissprot - Q4VWZ5
Ensembl - ENSMUSG00000026385
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dbiENSDARG00000026369Danio rerio
 DBIENSGALG00000012112Gallus gallus
 DBIENSG00000155368Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Acbd7 / Q9D258 / acyl-Coenzyme A binding domain containing 7 / Q8N6N7* / acyl-CoA binding domain containing 7*ENSMUSG0000002664433
Acbd5 / Q5XG73 / acyl-Coenzyme A binding domain containing 5 / Q5T8D3* / acyl-CoA binding domain containing 5*ENSMUSG0000002678130
Dbil5 / O09035 / Diazepam-binding inhibitor-like 5 ENSMUSG0000003805727
Acbd6 / Q9D061 / acyl-Coenzyme A binding domain containing 6 / Q9BR61* / acyl-CoA binding domain containing 6*ENSMUSG0000003370122
Acbd4 / acyl-Coenzyme A binding domain containing 4 / Q8NC06* / acyl-CoA binding domain containing 4*ENSMUSG0000005693822


Protein motifs (from Interpro)
Interpro ID Name
 IPR000582  Acyl-CoA-binding protein, ACBP
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR022408  Acyl-CoA-binding protein, ACBP, conserved site
 IPR035984  Acyl-CoA binding protein superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IDA
 biological_processGO:0001942 hair follicle development IMP
 biological_processGO:0006641 triglyceride metabolic process IMP
 biological_processGO:0007611 learning or memory IDA
 biological_processGO:0021670 lateral ventricle development IDA
 biological_processGO:0032228 regulation of synaptic transmission, GABAergic ISO
 biological_processGO:0036151 phosphatidylcholine acyl-chain remodeling IEA
 biological_processGO:0043588 skin development IMP
 biological_processGO:0060291 long-term synaptic potentiation IDA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0008021 synaptic vesicle ISO
 cellular_componentGO:0097038 perinuclear endoplasmic reticulum ISO
 molecular_functionGO:0000062 fatty-acyl-CoA binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0036042 long-chain fatty acyl-CoA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Mitochondrial Fatty Acid Beta-Oxidation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tmem173tm1Gnb/Tmem173tm1Gnb
Genetic Background: involves: 129P2/OlaHsd

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dbitm2.1Smdp/Dbi+,Dbitm2.2Smdp/Dbi+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA * FVB/N

Allelic Composition: Dbitm1Smdp/Dbitm1Smdp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Tmem173tm1Gnb/Tmem173tm1Gnb
Genetic Background: involves: 129P2/OlaHsd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Tmem173tm1Gnb/Tmem173tm1Gnb
Genetic Background: involves: 129P2/OlaHsd

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tmem173tm1Gnb/Tmem173tm1Gnb
Genetic Background: involves: 129P2/OlaHsd

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Tmem173tm1Gnb/Tmem173tm1Gnb
Genetic Background: involves: 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spo11tm3Rdco/Spo11tm3Rdco
Genetic Background: involves: C57BL/6

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Dbitm2.1Smdp/Dbi+,Dbitm2.2Smdp/Dbi+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA * FVB/N

 MP:0003849 greasy coat "fur is oily in appearance or texture" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dbitm2.1Smdp/Dbi+,Dbitm2.2Smdp/Dbi+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA * FVB/N

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tmem173tm1Gnb/Tmem173tm1Gnb
Genetic Background: involves: 129P2/OlaHsd

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
Show

Allelic Composition: Tmem173tm1Gnb/Tmem173tm1Gnb
Genetic Background: involves: 129P2/OlaHsd

 MP:0005670 abnormal white fat physiology "functional aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dbitm2.1Smdp/Dbi+,Dbitm2.2Smdp/Dbi+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA * FVB/N

Allelic Composition: Dbitm1Smdp/Dbitm1Smdp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmem173tm1Gnb/Tmem173tm1Gnb
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Dbitm1Smdp/Dbitm1Smdp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010027 increased liver cholesterol level "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmem173tm1Gnb/Tmem173tm1Gnb
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Dbitm2.1Smdp/Dbi+,Dbitm2.2Smdp/Dbi+,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Dbitm1Smdp/Dbitm1Smdp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
Show

Allelic Composition: Tmem173tm1Gnb/Tmem173tm1Gnb
Genetic Background: involves: 129P2/OlaHsd

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1Fan/Gt(ROSA)26Sortm1Fan,Tg(T-cre)1Lwd/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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