ENSMUSG00000026430


Mus musculus

Features
Gene ID: ENSMUSG00000026430
  
Biological name :Rassf5
  
Synonyms : Q5EBH1 / Ras association domain-containing protein 5 / Rassf5
  
Possible biological names infered from orthology : Q8WWW0 / Ras association domain family member 5
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E4
Gene start: 131176410
Gene end: 131245258
  
Corresponding Affymetrix probe sets: 10357594 (MoGene1.0st)   1422637_at (Mouse Genome 430 2.0 Array)   1422638_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108061
Ensembl peptide - ENSMUSP00000148646
Ensembl peptide - ENSMUSP00000027688
Ensembl peptide - ENSMUSP00000067011
NCBI entrez gene - 54354     See in Manteia.
MGI - MGI:1926375
RefSeq - NM_001311094
RefSeq - NM_001313731
RefSeq - NM_018750
RefSeq Peptide - NP_001300660
RefSeq Peptide - NP_061220
RefSeq Peptide - NP_001298023
swissprot - Q5EBH1
swissprot - A0A1D5RM65
swissprot - D3Z6G2
Ensembl - ENSMUSG00000026430
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RASSF5ENSDARG00000070601Danio rerio
 RASSF5ENSGALG00000038943Gallus gallus
 Q8WWW0ENSG00000266094Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99MK9 / Rassf1 / Ras association (RalGDS/AF-6) domain family member 1 / Q9NS23* / Ras association domain family member 1*ENSMUSG0000001006737
Q99P51 / Rassf3 / Ras association domain-containing protein 3 / Q86WH2* / Ras association domain family member 3*ENSMUSG0000002579525


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011524  SARAH domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR033614  C-terminal RASSF family
 IPR033623  Ras association domain-containing protein 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0031398 positive regulation of protein ubiquitination IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:1900180 regulation of protein localization to nucleus IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017016 Ras GTPase binding IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abl1tm1.1Gcos/Abl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abl1tm1.1Gcos/Abl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Abl1tm1.1Gcos/Abl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Abl1tm1.1Gcos/Abl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002223 lymphoid hypoplasia "decreased cell number in lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002343 abnormal lymph node cortex "anomaly in the outer area of the lymph node that has B and T cell domains" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002375 abnormal thymus medulla morphology "anomalous structure or development of the inner area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abl1tm1.1Gcos/Abl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abl1tm1.1Gcos/Abl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Abl1tm1.1Gcos/Abl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdkn1btm2Kin/Cdkn1btm2Kin,Rassf5tm1Kina/Rassf5tm1Kina
Genetic Background: involves: C57BL/6 * CBA

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
Show

Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Abl1tm1.1Gcos/Abl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Abl1tm1.1Gcos/Abl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abl1tm1.1Gcos/Abl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abl1tm1.1Gcos/Abl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abl1tm1.1Gcos/Abl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abl1tm1.1Gcos/Abl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abl1tm1.1Gcos/Abl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abl1tm1.1Gcos/Abl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abl1tm1.1Gcos/Abl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008827 abnormal thymus cell ratio "deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008828 abnormal lymph node cell ratio "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009543 abnormal thymus corticomedullary boundary morphology "any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
Show

Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm1(tetO-mCherry)Eggn/Col1a1tm1(tetO-mCherry)Eggn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0013502 decreased fibroblast apoptosis "reduction in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Col1a1tm1(tetO-mCherry)Eggn/Col1a1tm1(tetO-mCherry)Eggn
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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