| MP:0000111 | cleft palate | "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
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Allelic Composition: H2afvTg(Wnt1-cre)11Rth/0,Wnt5atm1Amc/Wnt5atm1.1Krvl
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * CBA/J
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| MP:0000522 | cysts in kidney cortex | "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844] |
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Allelic Composition: Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky/Gt(ROSA)26Sor+
Genetic Background: C57BL/6N-Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky
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| MP:0000562 | polydactyly | "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: H2afvTg(Wnt1-cre)11Rth/0,Wnt5atm1Amc/Wnt5atm1.1Krvl
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * CBA/J
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| MP:0000820 | abnormal choroid plexus morphology | "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302] |
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Allelic Composition: H2afvTg(Wnt1-cre)11Rth/0,Wnt5atm1Amc/Wnt5atm1.1Krvl
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * CBA/J
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| MP:0001004 | abnormal photoreceptor morphology | "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky/Gt(ROSA)26Sor+
Genetic Background: C57BL/6N-Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky
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| MP:0001326 | retinal degeneration | "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator] |
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Allelic Composition: Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky/Gt(ROSA)26Sor+
Genetic Background: C57BL/6N-Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky
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| MP:0002001 | blindness | "loss of the sense of sight" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky/Gt(ROSA)26Sor+
Genetic Background: C57BL/6N-Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky
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| MP:0002135 | abnormal kidney morphology | "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky/Gt(ROSA)26Sor+
Genetic Background: C57BL/6N-Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky
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| MP:0002705 | dilated renal tubules | "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky/Gt(ROSA)26Sor+
Genetic Background: C57BL/6N-Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky
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| MP:0003068 | enlarged kidney | "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky/Gt(ROSA)26Sor+
Genetic Background: C57BL/6N-Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky
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| MP:0003215 | renal interstitial fibrosis | "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission] |
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Allelic Composition: Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky/Gt(ROSA)26Sor+
Genetic Background: C57BL/6N-Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky
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| MP:0003675 | kidney cysts | "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky/Gt(ROSA)26Sor+
Genetic Background: C57BL/6N-Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky
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| MP:0006009 | abnormal neuronal migration | "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: H2afvTg(Wnt1-cre)11Rth/0,Wnt5atm1Amc/Wnt5atm1.1Krvl
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * CBA/J
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| MP:0008057 | abnormal DNA replication | "any anomaly in the process whereby new strands of DNA are synthesized" [GO:0006260] |
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Allelic Composition: Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky/Gt(ROSA)26Sor+
Genetic Background: C57BL/6N-Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky
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| MP:0008446 | decreased retinal cone cell number | "reduced number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky/Gt(ROSA)26Sor+
Genetic Background: C57BL/6N-Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky
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| MP:0008450 | retinal photoreceptor degeneration | "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky/Gt(ROSA)26Sor+
Genetic Background: C57BL/6N-Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky
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| MP:0008518 | retinal outer nuclear layer degeneration | "a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky/Gt(ROSA)26Sor+
Genetic Background: C57BL/6N-Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky
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| MP:0008535 | enlarged lateral ventricles | "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: H2afvTg(Wnt1-cre)11Rth/0,Wnt5atm1Amc/Wnt5atm1.1Krvl
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * CBA/J
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| MP:0008580 | photoreceptor inner segment degeneration | "retrogressive pathologic change in the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky/Gt(ROSA)26Sor+
Genetic Background: C57BL/6N-Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky
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| MP:0008584 | photoreceptor outer segment degeneration | "retrogressive pathologic change in the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky/Gt(ROSA)26Sor+
Genetic Background: C57BL/6N-Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: H2afvTg(Wnt1-cre)11Rth/0,Wnt5atm1Amc/Wnt5atm1.1Krvl
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * CBA/J
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| MP:0011308 | kidney corticomedullary cysts | "development of abnormal membranous sacs in the corticomedullary junction of the kidney" [MGI:anna] |
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Allelic Composition: Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky/Gt(ROSA)26Sor+
Genetic Background: C57BL/6N-Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky
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| MP:0011376 | abnormal kidney corticomedullary boundary morphology | "any structural anomaly of the region demarcating the renal medulla from the surrounding cortex; end-stage renal failure may be associated with loss of the normal corticomedullary boundary" [MGI:anna] |
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Allelic Composition: Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky/Gt(ROSA)26Sor+
Genetic Background: C57BL/6N-Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky
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| MP:0011682 | renal glomerulus cysts | "abnormal membranous sacs in any portion of the renal glomerulus" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky/Gt(ROSA)26Sor+
Genetic Background: C57BL/6N-Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky
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| MP:0012029 | abnormal electroretinogram waveform feature | "any anomaly in the pattern of the graphic record of the integrated ensemble response from many vision related neuronal and glial populations as a consequence of the serial processing within the retina, represented as changes in voltage over time after visual photonic stimulation" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky/Gt(ROSA)26Sor+
Genetic Background: C57BL/6N-Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky
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| MP:0013205 | abnormal nonmotile primary cilium morphology | "any structural anomaly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors; nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules" [GO:0031513] |
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Allelic Composition: H2afvTg(Wnt1-cre)11Rth/0,Wnt5atm1Amc/Wnt5atm1.1Krvl
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * CBA/J
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