ENSMUSG00000026605


Mus musculus

Features
Gene ID: ENSMUSG00000026605
  
Biological name :Cenpf
  
Synonyms : Cenpf / centromere protein F
  
Possible biological names infered from orthology : P49454
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H6
Gene start: 189640606
Gene end: 189688086
  
Corresponding Affymetrix probe sets: 10360985 (MoGene1.0st)   1427161_at (Mouse Genome 430 2.0 Array)   1452334_at (Mouse Genome 430 2.0 Array)   1458447_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000129738
Ensembl peptide - ENSMUSP00000132759
Ensembl peptide - ENSMUSP00000132430
Ensembl peptide - ENSMUSP00000130308
NCBI entrez gene - 108000     See in Manteia.
MGI - MGI:1313302
RefSeq - XM_017320925
RefSeq - NM_001081363
RefSeq - XM_006497119
RefSeq Peptide - NP_001074832
swissprot - E9Q3P4
swissprot - E9Q776
swissprot - E9PY14
swissprot - F6V6F0
Ensembl - ENSMUSG00000026605
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkeyp-115e12.6ENSDARG00000090986Danio rerio
 CENPFENSGALG00000009690Gallus gallus
 CENPFENSG00000117724Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR018302  Kinetochore protein Cenp-F/LEK1, Rb protein-binding domain
 IPR018463  Centromere protein Cenp-F, N-terminal
 IPR019513  Centromere protein Cenp-F, leucine-rich repeat-containing domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle ISO
 biological_processGO:0001822 kidney development ISO
 biological_processGO:0007059 chromosome segregation ISO
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle ISO
 biological_processGO:0015031 protein transport ISO
 biological_processGO:0016202 regulation of striated muscle tissue development IDA
 biological_processGO:0021591 ventricular system development ISO
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0051310 metaphase plate congression ISO
 cellular_componentGO:0000775 chromosome, centromeric region ISO
 cellular_componentGO:0000922 spindle pole ISO
 cellular_componentGO:0000940 condensed chromosome outer kinetochore ISO
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005635 nuclear envelope ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005819 spindle ISO
 cellular_componentGO:0005930 axoneme IDA
 cellular_componentGO:0016363 nuclear matrix ISO
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0036064 ciliary basal body IDA
 cellular_componentGO:0045120 pronucleus IDA
 cellular_componentGO:0097539 ciliary transition fiber ISO
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0070840 dynein complex binding ISO


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
Show

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0003057 abnormal epicardium morphology "anomalous structure of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0003105 abnormal heart atrium morphology "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0003896 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004071 prolonged P wave "increase in the length of time of the P wave electrical impulses" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0006267 abnormal intercalated disc morphology "any structural abnormality in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:64280]
Show

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0010503 myocardial trabeculae hypoplasia "underdevelopment or reduced size of the supporting bundles of muscular fibers lining the walls of the heart, usually due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0010508 abnormal heart electrocardiography waveform feature "any anomaly in the pattern of the graphic record of the integrated action currents of the cardiac cycle represented as changes in voltage; the prominent waves in the ECG correspond to specific conduction activity in areas of the heart and the timing and amplitude of ECG waveforms provide valuable information about heart rate and rhythm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:20410536]
Show

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0011395 decreased fetal cardiomyocyte proliferation "reduced ability of the differentiating cardiac muscle cell population to undergo expansion by cell division" [MGI:csmith]
Show

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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