ENSMUSG00000026650


Mus musculus

Features
Gene ID: ENSMUSG00000026650
  
Biological name :Meig1
  
Synonyms : Meig1 / Mus musculus meiosis expressed 1 (Meig1), transcript variant 3, mRNA. / Q61845
  
Possible biological names infered from orthology : meiosis/spermiogenesis associated 1 / Q5JSS6
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A1
Gene start: 3409043
Gene end: 3422648
  
Corresponding Affymetrix probe sets: 10479761 (MoGene1.0st)   1423410_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123118
Ensembl peptide - ENSMUSP00000110735
Ensembl peptide - ENSMUSP00000110736
Ensembl peptide - ENSMUSP00000070310
Ensembl peptide - ENSMUSP00000110733
Ensembl peptide - ENSMUSP00000110734
NCBI entrez gene - 104362     See in Manteia.
MGI - MGI:1202878
RefSeq - XM_006497308
RefSeq - NM_001355207
RefSeq - NM_008579
RefSeq - XM_006497307
RefSeq Peptide - NP_001342134
RefSeq Peptide - NP_001342137
RefSeq Peptide - NP_001342138
RefSeq Peptide - NP_001342139
RefSeq Peptide - NP_032605
RefSeq Peptide - NP_001342136
swissprot - A2AJG4
swissprot - Q61845
Ensembl - ENSMUSG00000026650
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 meig1ENSDARG00000045705Danio rerio
 MEIG1ENSGALG00000000451Gallus gallus
 MEIG1ENSG00000197889Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR020186  Meiosis-expressed gene 1 protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
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Allelic Composition: Myd88tm1Jcbr/Myd88tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Myd88tm1Jcbr Tg(Nes-cre)1Kln

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Grxcr1pi-2J/Grxcr1pi-2J
Genetic Background: DBA/2J-Grxcr1pi-2J/J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Myd88tm1Jcbr/Myd88tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Myd88tm1Jcbr Tg(Nes-cre)1Kln

Allelic Composition: Meig1tm1Shpi/Meig1tm1Shpi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myd88tm1Jcbr/Myd88tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Myd88tm1Jcbr Tg(Nes-cre)1Kln

Allelic Composition: Meig1tm1Shpi/Meig1tm1Shpi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Meig1tm1Shpi/Meig1tm1Shpi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myd88tm1Jcbr/Myd88tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Myd88tm1Jcbr Tg(Nes-cre)1Kln

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Meig1tm1Shpi/Meig1tm1Shpi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Meig1tm1Shpi/Meig1tm1Shpi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0008545 absent sperm flagella "mature spermatozoa lack a flagella" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Jcbr/Myd88tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Myd88tm1Jcbr Tg(Nes-cre)1Kln

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
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Allelic Composition: Meig1tm1Shpi/Meig1tm1Shpi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myd88tm1Jcbr/Myd88tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Myd88tm1Jcbr Tg(Nes-cre)1Kln

Allelic Composition: Meig1tm1Shpi/Meig1tm1Shpi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0009233 enlarged sperm head "increased size of the head segment of the sperm cell" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Meig1tm1Shpi/Meig1tm1Shpi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0009838 abnormal sperm axoneme morphology "any structural abnormality of the central core of the sperm flagellum, composed of a ring of 9 outer microtubule doublets surrounding a central pair; inner and outer dynein arms project from each of the outer 9 doublets, and these arms are responsible for generating the motive force of the flagellum; in addition, 9 radial spokes, each of which originates from 1 of the 9 outer microtubular doublet pairs, project inward toward the central pair in a helical fashion" [PMID:14581499]
Show

Allelic Composition: Myd88tm1Jcbr/Myd88tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Myd88tm1Jcbr Tg(Nes-cre)1Kln

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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