ENSMUSG00000026675


Mus musculus

Features
Gene ID: ENSMUSG00000026675
  
Biological name :Hsd17b7
  
Synonyms : Hsd17b7 / hydroxysteroid (17-beta) dehydrogenase 7 / O88736
  
Possible biological names infered from orthology : P56937
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H3
Gene start: 169949535
Gene end: 169969241
  
Corresponding Affymetrix probe sets: 10359917 (MoGene1.0st)   1417871_at (Mouse Genome 430 2.0 Array)   1440057_at (Mouse Genome 430 2.0 Array)   1448865_at (Mouse Genome 430 2.0 Array)   1457248_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027989
Ensembl peptide - ENSMUSP00000106985
NCBI entrez gene - 15490     See in Manteia.
MGI - MGI:1330808
RefSeq - XM_017317108
RefSeq - NM_010476
RefSeq - XM_006496667
RefSeq - XM_011238758
RefSeq Peptide - NP_034606
swissprot - O88736
swissprot - Q8C5N9
Ensembl - ENSMUSG00000026675
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hsd17b7ENSDARG00000088140Danio rerio
 HSD17B7ENSGALG00000037852Gallus gallus
 P56937ENSG00000132196Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006695 cholesterol biosynthetic process IDA
 biological_processGO:0006703 estrogen biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000253 3-keto sterol reductase activity IDA
 molecular_functionGO:0004303 estradiol 17-beta-dehydrogenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Cholesterol biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Myctm1Jlc/Myctm1Jlc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000282 abnormal atrial septum morphology "abnormality in the wall between the atria of the heart, usually incomplete closure " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Il6ratm1.2Drew/Il6ratm1.2Drew
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N * FVB/N * SJL

 MP:0000288 abnormal pericardium morphology "malformation of the fibroserous membrane covering the heart and beginning of the great vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:54408]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Il6ratm1.2Drew/Il6ratm1.2Drew
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N * FVB/N * SJL

 MP:0000784 forebrain hypoplasia "reduced cell number in the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsd17b7tm1Mpo/Hsd17b7tm1Mpo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Myctm1Jlc/Myctm1Jlc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000936 small telencephalic vesicles "reduced size of the paired diverticula of the telencephalon, from which the forebrain develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Myctm1Jlc/Myctm1Jlc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Il6ratm1.2Drew/Il6ratm1.2Drew
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N * FVB/N * SJL

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myctm1Jlc/Myctm1Jlc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Myctm1Jlc/Myctm1Jlc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hsd17b7tm1Mpo/Hsd17b7tm1Mpo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Il6ratm1.2Drew/Il6ratm1.2Drew
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N * FVB/N * SJL

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Myctm1Jlc/Myctm1Jlc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Il6ratm1.2Drew/Il6ratm1.2Drew
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N * FVB/N * SJL

 MP:0002884 abnormal branchial arches "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hsd17b7tm1Mpo/Hsd17b7tm1Mpo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003658 abnormal capillaries "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]
Show

Allelic Composition: Hsd17b7tm1Mpo/Hsd17b7tm1Mpo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004096 abnormal midbrain-hindbrain boundary development "anomaly in the formation of the midbrain-hindbrain domain, comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; an organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myctm1Jlc/Myctm1Jlc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004567 decreased myocardial fiber number "decreased number of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Hsd17b7tm1Mpo/Hsd17b7tm1Mpo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hsd17b7tm1Mpo/Hsd17b7tm1Mpo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myctm1Jlc/Myctm1Jlc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hsd17b7tm1Mpo/Hsd17b7tm1Mpo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010656 thick myocardium "increased thickness of the heart muscle layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hsd17b7tm1Mpo/Hsd17b7tm1Mpo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Myctm1Jlc/Myctm1Jlc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hsd17b7tm1Mpo/Hsd17b7tm1Mpo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0012089 decreased midbrain size "size reduction or truncation of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith]
Show

Allelic Composition: Myctm1Jlc/Myctm1Jlc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0012090 midbrain hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith]
Show

Allelic Composition: Myctm1Jlc/Myctm1Jlc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0012263 decreased hindbrain size "size reduction or truncation of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived" [MGI:anna]
Show

Allelic Composition: Myctm1Jlc/Myctm1Jlc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0012264 hindbrain hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived" [MGI:anna]
Show

Allelic Composition: Myctm1Jlc/Myctm1Jlc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0012505 increased neural tube apoptosis "increase in the number of cells of the neural tube undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Hsd17b7tm1Mpo/Hsd17b7tm1Mpo
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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