ENSMUSG00000026814


Mus musculus

Features
Gene ID: ENSMUSG00000026814
  
Biological name :Eng
  
Synonyms : Endoglin / Eng / Q63961
  
Possible biological names infered from orthology : P17813
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 32646595
Gene end: 32682669
  
Corresponding Affymetrix probe sets: 10471486 (MoGene1.0st)   1417271_a_at (Mouse Genome 430 2.0 Array)   1432176_a_at (Mouse Genome 430 2.0 Array)   1443682_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000009705
Ensembl peptide - ENSMUSP00000108897
Ensembl peptide - ENSMUSP00000122186
Ensembl peptide - ENSMUSP00000130585
NCBI entrez gene - 13805     See in Manteia.
MGI - MGI:95392
RefSeq - NM_001146348
RefSeq - NM_001146350
RefSeq - NM_007932
RefSeq Peptide - NP_001139822
RefSeq Peptide - NP_001139820
RefSeq Peptide - NP_031958
swissprot - Q3UAM9
swissprot - F7A1B4
swissprot - Q63961
swissprot - F7BZW0
Ensembl - ENSMUSG00000026814
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENGENSGALG00000033039Gallus gallus
 ENGENSG00000106991Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tgfbr3 / transforming growth factor, beta receptor III / Q03167* / transforming growth factor beta receptor 3*ENSMUSG0000002928725
Tgfbr3l / transforming growth factor beta receptor 3 like / H3BV60*ENSMUSG000000897366


Protein motifs (from Interpro)
Interpro ID Name
 IPR001507  Zona pellucida domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0001300 chronological cell aging IEP
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IMP
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0001666 response to hypoxia ISO
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001937 negative regulation of endothelial cell proliferation ISO
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003084 positive regulation of systemic arterial blood pressure ISO
 biological_processGO:0003148 outflow tract septum morphogenesis IGI
 biological_processGO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation IMP
 biological_processGO:0003203 endocardial cushion morphogenesis IMP
 biological_processGO:0003208 cardiac ventricle morphogenesis IMP
 biological_processGO:0003209 cardiac atrium morphogenesis IMP
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis IMP
 biological_processGO:0003273 cell migration involved in endocardial cushion formation IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IC
 biological_processGO:0007507 heart development IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0016477 cell migration ISO
 biological_processGO:0017015 regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0022009 central nervous system vasculogenesis IEA
 biological_processGO:0022617 extracellular matrix disassembly ISO
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0030513 positive regulation of BMP signaling pathway IEA
 biological_processGO:0031953 negative regulation of protein autophosphorylation IEA
 biological_processGO:0035912 dorsal aorta morphogenesis IMP
 biological_processGO:0042060 wound healing ISO
 biological_processGO:0045766 positive regulation of angiogenesis TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048745 smooth muscle tissue development IMP
 biological_processGO:0048844 artery morphogenesis IMP
 biological_processGO:0048845 venous blood vessel morphogenesis IMP
 biological_processGO:0048870 cell motility ISO
 biological_processGO:0051001 negative regulation of nitric-oxide synthase activity ISO
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0055009 atrial cardiac muscle tissue morphogenesis IMP
 biological_processGO:0060326 cell chemotaxis ISO
 biological_processGO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation ISO
 biological_processGO:0070483 detection of hypoxia ISO
 biological_processGO:0097084 vascular smooth muscle cell development IMP
 biological_processGO:1905007 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation IMP
 biological_processGO:1905065 positive regulation of vascular smooth muscle cell differentiation IMP
 biological_processGO:1905222 atrioventricular canal morphogenesis IMP
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0072563 endothelial microparticle IDA
 molecular_functionGO:0005024 transforming growth factor beta-activated receptor activity ISO
 molecular_functionGO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity IEA
 molecular_functionGO:0005114 type II transforming growth factor beta receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005534 galactose binding IEA
 molecular_functionGO:0005539 glycosaminoglycan binding IEA
 molecular_functionGO:0034713 type I transforming growth factor beta receptor binding IEA
 molecular_functionGO:0036122 BMP binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0050431 transforming growth factor beta binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000265 atretic vasculature "absence or disorganization of vasculature" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571]
Show

Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Engtm1Mle/Engtm1Mle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
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Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Engtm1Mle/Engtm1Mle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000420 ruffled hair "fuzzy, irregular appearance of the hair" [J:50844]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Engtm2.1Hma/Engtm2.1Hma,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
Show

Allelic Composition: Engtm2.1Hma/Engtm2.1Hma,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Engtm1Hma/Eng+
Genetic Background: 129P2/OlaHsd-Engtm1Hma

Allelic Composition: Engtm2.1Hma/Engtm2.1Hma,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Engtm2.1Hma/Engtm2.1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
Show

Allelic Composition: Engtm1Mle/Engtm1Mle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Engtm1Mle/Engtm1Mle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Engtm1Mle/Eng+
Genetic Background: 129P2/OlaHsd-Engtm1Mle

Allelic Composition: Engtm2.1Hma/Engtm2.1Hma,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Engtm2.1Hma/Engtm2.1Hma,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkacatm1Gsm/Prkacatm1Gsm,Prkacbtm1Gsm/Prkacb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Engtm2.1Hma/Engtm2.1Hma,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Msr1tm1Csk/Msr1tm1Csk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Engtm2.1Hma/Engtm2.1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002884 abnormal branchial arches "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Engtm1Mle/Engtm1Mle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Engtm1Mle/Engtm1Mle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Engtm2.2Hma/Engtm2.2Hma
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0003396 abnormal embryonic hematopoiesis "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans " [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003658 abnormal capillaries "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]
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Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Engtm1Mle/Engtm1Mle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003974 abnormal endocardium morphology "malformation of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Engtm1Mle/Engtm1Mle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Engtm1Mle/Engtm1Mle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004086 absent heartbeat "lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus)" [J:69362, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Engtm1Mle/Engtm1Mle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004176 ear telangiectases "vascular lesion formed by dilation of a group of small blood vessels in the ear" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Engtm1Mle/Eng+
Genetic Background: 129P2/OlaHsd-Engtm1Mle

 MP:0004177 tail telangiectases "vascular lesion formed by dilation of a group of small blood vessels in the tail" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Engtm1Mle/Eng+
Genetic Background: 129P2/OlaHsd-Engtm1Mle

 MP:0004178 neck telangiectases "vascular lesion formed by dilation of a group of small blood vessels in the neck" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0004181 abnormal carotid artery morphology "malformation of any of the four arteries (two on each side of the neck; right and left internal carotid arteries, and right and left external carotid arteries) that deliver oxygen-rich blood from the heart to the head and brain" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Engtm2.1Hma/Engtm2.1Hma,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Engtm2.1Hma/Engtm2.1Hma,Tg(Tal1-cre/ERT)1Jrg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Engtm2.1Hma/Engtm2.1Hma,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005435 hemoperitoneum "blood in the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87293]
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Allelic Composition: Engtm1Mle/Engtm1Mle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Engtm1Hma/Eng+
Genetic Background: 129P2/OlaHsd-Engtm1Hma

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006093 arteriovenous malformation "fusion of an artery and vein without an intervening capillary bed" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93125]
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Allelic Composition: Engtm2.1Hma/Engtm2.1Hma,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Engtm2.1Hma/Engtm2.1Hma,Tg(Tal1-cre/ERT)1Jrg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Engtm2.1Hma/Engtm2.1Hma,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010530 cerebral arteriovenous malformation "congenital vascular anomaly in the cerebrum characterized by direct communication between an artery and a vein without passing through the capillary bed" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010531 gastrointestinal arteriovenous malformation "congenital vascular anomaly in the gastrointestinal system characterized by direct communication between an artery and a vein without passing through the capillary bed" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Engtm2.1Hma/Engtm2.1Hma,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Engtm2.2Hma/Engtm2.2Hma
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Engtm1Mle/Engtm1Mle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011204 abnormal visceral yolk sac blood island morphology "any structural anomaly of the masses of developing blood cells attached to endothelium in the yolk sac" [PMID:16140152]
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Allelic Composition: Engtm1Mle/Engtm1Mle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012253 abnormal intersomitic vessel morphology "any structural anomaly of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna]
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Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012732 abnormal perineural vascular plexus morphology "any structural anomaly of the capillary bed that initially surrounds the relative avascular brain and spinal cord; the perineural vascular plexus (PNVP) is the precursor to the blood brain barrier formed by angioblasts which migrate away from somites and is recruited to surround the neural tube in response to VEGF; vascularization of the brain and spinal cord occurs via angiogenesis as sprouting vessels from the PNVP invade the neuroepithelium and grow inward toward the ventricular lumen" [MGI:anna]
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Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013139 moribund "in terminal decline and approaching death; lacking vitality or vigor and becoming unresponsive" [MGI:Ahmad_Retha]
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Allelic Composition: Engtm2.1Hma/Engtm2.1Hma,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0013241 embryo tissue necrosis "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]
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Allelic Composition: Engtm1Mle/Engtm1Mle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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