ENSMUSG00000026817


Mus musculus

Features
Gene ID: ENSMUSG00000026817
  
Biological name :Ak1
  
Synonyms : Adenylate kinase isoenzyme 1 / Ak1 / Q9R0Y5
  
Possible biological names infered from orthology : adenylate kinase 1 / P00568
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 32621758
Gene end: 32635058
  
Corresponding Affymetrix probe sets: 10471474 (MoGene1.0st)   1422184_a_at (Mouse Genome 430 2.0 Array)   1423988_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108902
Ensembl peptide - ENSMUSP00000123534
Ensembl peptide - ENSMUSP00000142174
Ensembl peptide - ENSMUSP00000068479
Ensembl peptide - ENSMUSP00000108903
NCBI entrez gene - 11636     See in Manteia.
MGI - MGI:87977
RefSeq - NM_001198792
RefSeq - NM_001198790
RefSeq - NM_001198791
RefSeq - NM_021515
RefSeq - XM_006497624
RefSeq - XM_017315020
RefSeq Peptide - NP_001185721
RefSeq Peptide - NP_067490
RefSeq Peptide - NP_001185719
RefSeq Peptide - NP_001185720
swissprot - Q9R0Y5
swissprot - A0A0A6YXW8
swissprot - Z4YN97
Ensembl - ENSMUSG00000026817
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ak1ENSDARG00000001950Danio rerio
 AK1ENSGALG00000029150Gallus gallus
 AK1ENSG00000106992Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ak5 / Q920P5 / Adenylate kinase isoenzyme 5 / Q9Y6K8* / adenylate kinase 5*ENSMUSG0000003905853
Gm17949ENSMUSG0000010973942
Cmpk1 / cytidine/uridine monophosphate kinase 1 / P30085*ENSMUSG0000002871937


Protein motifs (from Interpro)
Interpro ID Name
 IPR000850  Adenylate kinase/UMP-CMP kinase
 IPR006267  Adenylate kinase, isozyme 1/5
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR028582  Adenylate kinase isoenzyme 1
 IPR033690  Adenylate kinase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006139 nucleobase-containing compound metabolic process IEA
 biological_processGO:0006165 nucleoside diphosphate phosphorylation ISO
 biological_processGO:0007050 cell cycle arrest IDA
 biological_processGO:0009142 nucleoside triphosphate biosynthetic process ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0046034 ATP metabolic process IEA
 cellular_componentGO:0001520 outer dense fiber IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0036126 sperm flagellum IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004017 adenylate kinase activity ISO
 molecular_functionGO:0004550 nucleoside diphosphate kinase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019205 nucleobase-containing compound kinase activity IEA


Pathways (from Reactome)
Pathway description
Interconversion of nucleotide di- and triphosphates


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4+,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * FVB

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4+,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * FVB

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4+,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * FVB

 MP:0003806 abnormal nucleotide metabolism "impaired regulation of nucleotide levels in either production or breakdown of these structural components of nucleic acids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gsc2tm1Bhr/Gsc2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ak1tm1Bew/Ak1tm1Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005450 abnormal energy expenditure "utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4+,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * FVB

 MP:0005620 abnormal muscle contractility "aberrant ability of a muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gsc2tm1Bhr/Gsc2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010957 abnormal aerobic respiration "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060]
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Allelic Composition: Gsc2tm1Bhr/Gsc2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010958 abnormal tricarboxylic acid cycle "any anomaly in the universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes; the acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle" [GO:0006099]
Show

Allelic Composition: Ak1tm1Bew/Ak1tm1Bew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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