ENSMUSG00000026819


Mus musculus

Features
Gene ID: ENSMUSG00000026819
  
Biological name :Slc25a25
  
Synonyms : A2ASZ8 / Calcium-binding mitochondrial carrier protein SCaMC-2 / Slc25a25
  
Possible biological names infered from orthology : Q6KCM7 / solute carrier family 25 member 25
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: B
Gene start: 32414487
Gene end: 32451445
  
Corresponding Affymetrix probe sets: 10481634 (MoGene1.0st)   1424735_at (Mouse Genome 430 2.0 Array)   1447856_x_at (Mouse Genome 430 2.0 Array)   1454284_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121932
Ensembl peptide - ENSMUSP00000115617
Ensembl peptide - ENSMUSP00000141486
Ensembl peptide - ENSMUSP00000028160
Ensembl peptide - ENSMUSP00000060581
Ensembl peptide - ENSMUSP00000108932
Ensembl peptide - ENSMUSP00000108933
Ensembl peptide - ENSMUSP00000108936
NCBI entrez gene - 227731     See in Manteia.
MGI - MGI:1915913
RefSeq - NM_001164357
RefSeq - NM_001164358
RefSeq - NM_001290558
RefSeq - NM_146118
RefSeq - XM_006497954
RefSeq - XM_006497955
RefSeq - XM_006497957
RefSeq - XM_006497958
RefSeq Peptide - NP_001157829
RefSeq Peptide - NP_001277487
RefSeq Peptide - NP_666230
RefSeq Peptide - NP_001157830
swissprot - Z4YLR9
swissprot - F6RC04
swissprot - A2ASZ8
swissprot - A0A0A6YWC1
Ensembl - ENSMUSG00000026819
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A2CEQ0ENSDARG00000035468Danio rerio
 Q6NYZ6ENSDARG00000010572Danio rerio
 SLC25A25ENSGALG00000005095Gallus gallus
 Q6KCM7ENSG00000148339Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6GQS1 / Slc25a23 / solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 / Q9BV35* / solute carrier family 25 member 23*ENSMUSG0000004632959
Q8BMD8 / Slc25a24 / Calcium-binding mitochondrial carrier protein SCaMC-1 / Q6NUK1* / solute carrier family 25 member 24*ENSMUSG0000004032257
Slc25a54 / solute carrier family 25, member 54ENSMUSG0000002788047
Q8BVN7 / Slc25a41 / Solute carrier family 25 member 41 / Q8N5S1*ENSMUSG0000001148633
Q8R0Y8 / Slc25a42 / Mitochondrial coenzyme A transporter SLC25A42 / Q86VD7* / solute carrier family 25 member 42*ENSMUSG0000000234622
A2A3V2 / Slc25a43 / Solute carrier family 25 member 43 / Q8WUT9*ENSMUSG0000003763617


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR002067  Mitochondrial carrier protein
 IPR002167  Graves disease carrier protein
 IPR011992  EF-hand domain pair
 IPR018108  Mitochondrial substrate/solute carrier
 IPR023395  Mitochondrial carrier domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002021 response to dietary excess IMP
 biological_processGO:0006839 mitochondrial transport IBA
 biological_processGO:0014823 response to activity IMP
 biological_processGO:0015866 ADP transport IEA
 biological_processGO:0015867 ATP transport IEA
 biological_processGO:0032094 response to food IMP
 biological_processGO:0035264 multicellular organism growth IGI
 biological_processGO:0043010 camera-type eye development IGI
 biological_processGO:0045333 cellular respiration IMP
 biological_processGO:0046034 ATP metabolic process IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060612 adipose tissue development IMP
 biological_processGO:0070588 calcium ion transmembrane transport IMP
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005347 ATP transmembrane transporter activity IBA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0015217 ADP transmembrane transporter activity IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Gpd2tm1Lbr/Gpd2tm1Lbr,Slc25a25tm1.1Kz/Slc25a25tm1.1Kz
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Gpd2tm1Lbr/Gpd2tm1Lbr,Slc25a25tm1.1Kz/Slc25a25tm1.1Kz
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gpd2tm1Lbr/Gpd2tm1Lbr,Slc25a25tm1.1Kz/Slc25a25tm1.1Kz
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0003060 increased aerobic running capacity "greater ability to run at defined speeds and/or distances compared to controls" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Map2k7tm1.1Twad/Map2k7tm1.2Twad,Tg(MMTV-cre)4Mam/0,Tg(MMTV-Erbb2)1Pv/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N

 MP:0003061 decreased aerobic running capacity "reduced ability to run at defined speeds and/or distances compared to controls" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Map2k7tm1.1Twad/Map2k7tm1.2Twad,Tg(MMTV-cre)4Mam/0,Tg(MMTV-Erbb2)1Pv/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Map2k7tm1.1Twad/Map2k7tm1.2Twad,Tg(MMTV-cre)4Mam/0,Tg(MMTV-Erbb2)1Pv/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Map2k7tm1.1Twad/Map2k7tm1.2Twad,Tg(MMTV-cre)4Mam/0,Tg(MMTV-Erbb2)1Pv/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N

 MP:0005448 abnormal energy balance "aberrant intake or expenditure of calories as compared to the normal state" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Map2k7tm1.1Twad/Map2k7tm1.2Twad,Tg(MMTV-cre)4Mam/0,Tg(MMTV-Erbb2)1Pv/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N

 MP:0005452 abnormal body fat amount "more or less than the normal total amount of connective tissue composed of fat cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Map2k7tm1.1Twad/Map2k7tm1.2Twad,Tg(MMTV-cre)4Mam/0,Tg(MMTV-Erbb2)1Pv/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Map2k7tm1.1Twad/Map2k7tm1.2Twad,Tg(MMTV-cre)4Mam/0,Tg(MMTV-Erbb2)1Pv/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Map2k7tm1.1Twad/Map2k7tm1.2Twad,Tg(MMTV-cre)4Mam/0,Tg(MMTV-Erbb2)1Pv/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Map2k7tm1.1Twad/Map2k7tm1.2Twad,Tg(MMTV-cre)4Mam/0,Tg(MMTV-Erbb2)1Pv/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N

 MP:0010182 decreased susceptibility to weight gain "smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Map2k7tm1.1Twad/Map2k7tm1.2Twad,Tg(MMTV-cre)4Mam/0,Tg(MMTV-Erbb2)1Pv/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gpd2tm1Lbr/Gpd2tm1Lbr,Slc25a25tm1.1Kz/Slc25a25tm1.1Kz
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Map2k7tm1.1Twad/Map2k7tm1.2Twad,Tg(MMTV-cre)4Mam/0,Tg(MMTV-Erbb2)1Pv/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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