ENSMUSG00000026822


Mus musculus

Features
Gene ID: ENSMUSG00000026822
  
Biological name :Lcn2
  
Synonyms : Lcn2 / Neutrophil gelatinase-associated lipocalin / P11672
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: B
Gene start: 32384633
Gene end: 32388252
  
Corresponding Affymetrix probe sets: 10481627 (MoGene1.0st)   1427747_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141430
Ensembl peptide - ENSMUSP00000053962
NCBI entrez gene - 16819     See in Manteia.
MGI - MGI:96757
RefSeq - NM_008491
RefSeq Peptide - NP_032517
swissprot - A0A0A6YW77
swissprot - P11672
Ensembl - ENSMUSG00000026822
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lcn12 / Q6JVL5 / Epididymal-specific lipocalin-12 / Q6JVE5* / lipocalin 12*ENSMUSG0000002694328


Protein motifs (from Interpro)
Interpro ID Name
 IPR000566  Lipocalin/cytosolic fatty-acid binding domain
 IPR002345  Lipocalin
 IPR003087  Neutrophil gelatinase-associated lipocalin/epididymal-specific lipocalin-12
 IPR012674  Calycin
 IPR022272  Lipocalin family conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0009615 response to virus IDA
 biological_processGO:0009617 response to bacterium IEA
 biological_processGO:0009635 response to herbicide IEA
 biological_processGO:0010046 response to mycotoxin IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0015891 siderophore transport IMP
 biological_processGO:0031346 positive regulation of cell projection organization IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0031669 cellular response to nutrient levels IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045087 innate immune response IMP
 biological_processGO:0055072 iron ion homeostasis IEA
 biological_processGO:0070207 protein homotrimerization IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005506 iron ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0036094 small molecule binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1Sia/Gt(ROSA)26Sortm1.1Sia
Genetic Background: involves: C57BL/6 * CBA * FVB/N

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1Sia/Gt(ROSA)26Sortm1.1Sia
Genetic Background: involves: C57BL/6 * CBA * FVB/N

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1Sia/Gt(ROSA)26Sortm1.1Sia
Genetic Background: involves: C57BL/6 * CBA * FVB/N

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1Sia/Gt(ROSA)26Sortm1.1Sia
Genetic Background: involves: C57BL/6 * CBA * FVB/N

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1Sia/Gt(ROSA)26Sortm1.1Sia
Genetic Background: involves: C57BL/6 * CBA * FVB/N

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1Sia/Gt(ROSA)26Sortm1.1Sia
Genetic Background: involves: C57BL/6 * CBA * FVB/N

 MP:0000708 thymus hyperplasia "increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1Sia/Gt(ROSA)26Sortm1.1Sia
Genetic Background: involves: C57BL/6 * CBA * FVB/N

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1Sia/Gt(ROSA)26Sortm1.1Sia
Genetic Background: involves: C57BL/6 * CBA * FVB/N

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Lcn2tm1Mak/Lcn2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdh2Gt(OST49160)Lex/Cdh2Gt(OST49160)Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Lcn2tm1Mak/Lcn2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1Sia/Gt(ROSA)26Sortm1.1Sia
Genetic Background: involves: C57BL/6 * CBA * FVB/N

Allelic Composition: Lcn2tm1Mrgr/Lcn2tm1Mrgr
Genetic Background: B6.129-Lcn2tm1Mrgr

Allelic Composition: Lcn2tm1Mrgr/Lcn2tm1Mrgr
Genetic Background: involves: 129 * C57BL/6

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1Sia/Gt(ROSA)26Sortm1.1Sia
Genetic Background: involves: C57BL/6 * CBA * FVB/N

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1Sia/Gt(ROSA)26Sortm1.1Sia
Genetic Background: involves: C57BL/6 * CBA * FVB/N

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1Sia/Gt(ROSA)26Sortm1.1Sia
Genetic Background: involves: C57BL/6 * CBA * FVB/N

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1Sia/Gt(ROSA)26Sortm1.1Sia
Genetic Background: involves: C57BL/6 * CBA * FVB/N

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1Sia/Gt(ROSA)26Sortm1.1Sia
Genetic Background: involves: C57BL/6 * CBA * FVB/N

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1Sia/Gt(ROSA)26Sortm1.1Sia
Genetic Background: involves: C57BL/6 * CBA * FVB/N

 MP:0005044 sepsis "presence of various pathogenic organisms, or their toxins, in the blood or tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:82434]
Show

Allelic Composition: Cdh2Gt(OST49160)Lex/Cdh2Gt(OST49160)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1Sia/Gt(ROSA)26Sortm1.1Sia
Genetic Background: involves: C57BL/6 * CBA * FVB/N

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1Sia/Gt(ROSA)26Sortm1.1Sia
Genetic Background: involves: C57BL/6 * CBA * FVB/N

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1Sia/Gt(ROSA)26Sortm1.1Sia
Genetic Background: involves: C57BL/6 * CBA * FVB/N

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1Sia/Gt(ROSA)26Sortm1.1Sia
Genetic Background: involves: C57BL/6 * CBA * FVB/N

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1Sia/Gt(ROSA)26Sortm1.1Sia
Genetic Background: involves: C57BL/6 * CBA * FVB/N

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0009542 decreased thymocyte apoptosis "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1Sia/Gt(ROSA)26Sortm1.1Sia
Genetic Background: involves: C57BL/6 * CBA * FVB/N

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdh2Gt(OST49160)Lex/Cdh2Gt(OST49160)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1Sia/Gt(ROSA)26Sortm1.1Sia
Genetic Background: involves: C57BL/6 * CBA * FVB/N

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0011178 increased erythroblast number "greater number of the nucleated precursor of erythrocytes" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1Sia/Gt(ROSA)26Sortm1.1Sia
Genetic Background: involves: C57BL/6 * CBA * FVB/N

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022199 Q9D9E0 / Slc22a17 / Solute carrier family 22 member 17 / Q8WUG5*  / complex






 

0 s.

 
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