| MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Cdkn2aem2Cjs/Cdkn2aem2Cjs
Genetic Background: C57BL/6-Cdkn2aem2Cjs
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| MP:0000286 | abnormal mitral valve morphology | "malformation of the valve between the left atrium and the left ventricle of the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Cdkn2aem2Cjs/Cdkn2aem2Cjs
Genetic Background: C57BL/6-Cdkn2aem2Cjs
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| MP:0000531 | right pulmonary isomerism | "bilaterally symmetric right lung pattern (or altered asymmetric patterning of the lung)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:58530] |
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Allelic Composition: Cdkn2aem2Cjs/Cdkn2aem2Cjs
Genetic Background: C57BL/6-Cdkn2aem2Cjs
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| MP:0000644 | dextrocardia | "cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Cdkn2aem2Cjs/Cdkn2aem2Cjs
Genetic Background: C57BL/6-Cdkn2aem2Cjs
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| MP:0000650 | mesocardia | "cardiac apex pointing to the middle as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Cdkn2aem2Cjs/Cdkn2aem2Cjs
Genetic Background: C57BL/6-Cdkn2aem2Cjs
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| MP:0000689 | abnormal spleen morphology | "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463] |
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Allelic Composition: Cdkn2aem2Cjs/Cdkn2aem2Cjs
Genetic Background: C57BL/6-Cdkn2aem2Cjs
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| MP:0001706 | abnormal left-right axis patterning | "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cdkn2aem2Cjs/Cdkn2aem2Cjs
Genetic Background: C57BL/6-Cdkn2aem2Cjs
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| MP:0002135 | abnormal kidney morphology | "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cdkn2aem2Cjs/Cdkn2aem2Cjs
Genetic Background: C57BL/6-Cdkn2aem2Cjs
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| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0002590 | increased mean corpuscular volume | "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0002633 | persistent truncus arteriosis | "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Cdkn2aem2Cjs/Cdkn2aem2Cjs
Genetic Background: C57BL/6-Cdkn2aem2Cjs
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| MP:0002740 | heart hypoplasia | "decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765] |
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Allelic Composition: Cdkn2aem2Cjs/Cdkn2aem2Cjs
Genetic Background: C57BL/6-Cdkn2aem2Cjs
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| MP:0003140 | dilated atria | "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Cdkn2aem2Cjs/Cdkn2aem2Cjs
Genetic Background: C57BL/6-Cdkn2aem2Cjs
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| MP:0003178 | left pulmonary isomerism | "bilaterally symmetric left lung pattern (or altered asymmetric patterning of the lung)" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93051] |
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Allelic Composition: Cdkn2aem2Cjs/Cdkn2aem2Cjs
Genetic Background: C57BL/6-Cdkn2aem2Cjs
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| MP:0003921 | abnormal left ventricle morphology | "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Cdkn2aem2Cjs/Cdkn2aem2Cjs
Genetic Background: C57BL/6-Cdkn2aem2Cjs
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| MP:0004066 | abnormal Henson s node morphology | "malformation of cells in the small pit at the anterior end of the primitive streak that are important in determining left-right asymmetry" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Cdkn2aem2Cjs/Cdkn2aem2Cjs
Genetic Background: C57BL/6-Cdkn2aem2Cjs
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| MP:0004133 | heterotaxia | "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Cdkn2aem2Cjs/Cdkn2aem2Cjs
Genetic Background: C57BL/6-Cdkn2aem2Cjs
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| MP:0008987 | abnormal liver lobule morphology | "any structural anomaly of the polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Cdkn2aem2Cjs/Cdkn2aem2Cjs
Genetic Background: C57BL/6-Cdkn2aem2Cjs
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| MP:0010117 | abnormal lateral plate mesoderm | "anomaly of the portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Cdkn2aem2Cjs/Cdkn2aem2Cjs
Genetic Background: C57BL/6-Cdkn2aem2Cjs
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| MP:0010402 | ventricular septal defect | "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540] |
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Allelic Composition: Cdkn2aem2Cjs/Cdkn2aem2Cjs
Genetic Background: C57BL/6-Cdkn2aem2Cjs
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| MP:0010420 | muscular ventricular septal defect | "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com] |
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Allelic Composition: Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0010595 | abnormal aortic valve cusp morphology | "any structural anomaly of the three fibrous triangular components and associated flap of the aortic valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0010808 | right-sided stomach | "stomach is present on the right side of the body instead of the left" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cdkn2aem2Cjs/Cdkn2aem2Cjs
Genetic Background: C57BL/6-Cdkn2aem2Cjs
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| MP:0010853 | abnormal lung position or orientation | "the lung is displaced from the normal position and/or has an altered left/right orientation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cdkn2aem2Cjs/Cdkn2aem2Cjs
Genetic Background: C57BL/6-Cdkn2aem2Cjs
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| MP:0010975 | abnormal lung lobe morphology | "any structural anomaly of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cdkn2aem2Cjs/Cdkn2aem2Cjs
Genetic Background: C57BL/6-Cdkn2aem2Cjs
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| MP:0011109 | partial lethality throughout fetal growth and development | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Cdkn2aem2Cjs/Cdkn2aem2Cjs
Genetic Background: C57BL/6-Cdkn2aem2Cjs
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| MP:0011252 | situs inversus totalis | "the complete right to left reversal (transposition) of the thoracic and abdominal organs, including the heart (dextrocardia)" [MGI:csmith] |
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Allelic Composition: Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: 1700007K13RikGt(OST3440)Lex/1700007K13RikGt(OST3440)Lex
Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6J) or (involves: 129S5/SvEvBrd * C57BL/6J * FVB/N)
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| MP:0013840 | absent segment of posterior cerebral artery | "absence of a portion of one of a pair of blood vessels that supplies oxygenated blood to the posterior aspect of the brain" [UBERON:0001636] |
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Allelic Composition: Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0013847 | retropleural edema | "accumulation of watery or serous fluid in the retropleural space" [MGI:csmith] |
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Allelic Composition: Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0013971 | blood in lymph vessels | |
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Allelic Composition: Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0014001 | abnormal vertebral artery topology | "abnormal position of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck" [MGI:csmith] |
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Allelic Composition: Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0014021 | heterochrony | |
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Allelic Composition: Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0020494 | left sided inferior vena cava | "the infrarenal segment of the inferior vena cava is present on the left side of the body instead of on the right side; typically as a result of regression of the right supracardinal vein and persistence of the left supracardinal vein" [http://www.sciencedirect.com/science/article/pii/S1533316707000374, https://radiopaedia.org/articles/transposition-of-inferior-vena-cava, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921701/] |
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Allelic Composition: 1700007K13RikGt(OST3440)Lex/1700007K13RikGt(OST3440)Lex
Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6J) or (involves: 129S5/SvEvBrd * C57BL/6J * FVB/N)
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