ENSMUSG00000026914


Mus musculus

Features
Gene ID: ENSMUSG00000026914
  
Biological name :Psmd14
  
Synonyms : 26S proteasome non-ATPase regulatory subunit 14 / O35593 / Psmd14
  
Possible biological names infered from orthology : O00487 / proteasome 26S subunit, non-ATPase 14
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C1.3
Gene start: 61711694
Gene end: 61800376
  
Corresponding Affymetrix probe sets: 10472300 (MoGene1.0st)   1421751_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028278
NCBI entrez gene - 59029     See in Manteia.
MGI - MGI:1913284
RefSeq - NM_021526
RefSeq Peptide - NP_067501
swissprot - O35593
Ensembl - ENSMUSG00000026914
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psmd14ENSDARG00000063100Danio rerio
 PSMD14ENSGALG00000011128Gallus gallus
 O00487ENSG00000115233Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000555  JAB1/MPN/MOV34 metalloenzyme domain
 IPR024969  Rpn11/EIF3F, C-terminal
 IPR035299  26S Proteasome non-ATPase regulatory subunit 14
 IPR037518  MPN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010950 positive regulation of endopeptidase activity IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0061136 regulation of proteasomal protein catabolic process IEA
 biological_processGO:0070536 protein K63-linked deubiquitination IEA
 cellular_componentGO:0000502 proteasome complex ISS
 cellular_componentGO:0008541 proteasome regulatory particle, lid subcomplex IEA
 cellular_componentGO:0022624 proteasome accessory complex IDA
 cellular_componentGO:0031597 cytosolic proteasome complex IEA
 molecular_functionGO:0004175 endopeptidase activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061133 endopeptidase activator activity IEA
 molecular_functionGO:0061578 Lys63-specific deubiquitinase activity IEA
 molecular_functionGO:0070628 proteasome binding IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Metalloprotease DUBs
Neutrophil degranulation
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr