ENSMUSG00000026977


Mus musculus

Features
Gene ID: ENSMUSG00000026977
  
Biological name :March7
  
Synonyms : E3 ubiquitin-protein ligase MARCH7 / March7 / Q9WV66
  
Possible biological names infered from orthology : membrane associated ring-CH-type finger 7 / Q9H992
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C1.1
Gene start: 60209887
Gene end: 60250676
  
Corresponding Affymetrix probe sets: 10472277 (MoGene1.0st)   1420609_at (Mouse Genome 430 2.0 Array)   1436893_a_at (Mouse Genome 430 2.0 Array)   1440966_at (Mouse Genome 430 2.0 Array)   1443329_at (Mouse Genome 430 2.0 Array)   1458690_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099808
Ensembl peptide - ENSMUSP00000099809
Ensembl peptide - ENSMUSP00000116925
Ensembl peptide - ENSMUSP00000068961
NCBI entrez gene - 57438     See in Manteia.
MGI - MGI:1931053
RefSeq - NM_020575
RefSeq Peptide - NP_065600
swissprot - Q9WV66
swissprot - F7B2M7
Ensembl - ENSMUSG00000026977
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 march7ENSDARG00000057772Danio rerio
 march7ENSDARG00000096375Danio rerio
 MARCH7ENSGALG00000012584Gallus gallus
 MARCH7ENSG00000136536Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
March10 / membrane associated ring-CH-type finger 10 / Q8NA82*ENSMUSG0000007862722


Protein motifs (from Interpro)
Interpro ID Name
 IPR011016  Zinc finger, RING-CH-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002643 regulation of tolerance induction IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0042130 negative regulation of T cell proliferation IMP
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1tm4Wbm,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1tm4Wbm,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1tm4Wbm,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1tm4Wbm,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

Allelic Composition: March7Gt(ROSABetageo)1Summ/March7+
Genetic Background: involves: BALB/c

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1tm4Wbm,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

Allelic Composition: March7Gt(ROSABetageo)1Summ/March7+
Genetic Background: involves: BALB/c

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1tm4Wbm,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

Allelic Composition: March7Gt(ROSABetageo)1Summ/March7+
Genetic Background: involves: BALB/c

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1tm4Wbm,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

Allelic Composition: March7Gt(ROSABetageo)1Summ/March7+
Genetic Background: involves: BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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