ENSMUSG00000026986


Mus musculus

Features
Gene ID: ENSMUSG00000026986
  
Biological name :Hnmt
  
Synonyms : Histamine N-methyltransferase / Hnmt / Q91VF2
  
Possible biological names infered from orthology : P50135
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A3
Gene start: 24002910
Gene end: 24049394
  
Corresponding Affymetrix probe sets: 10480459 (MoGene1.0st)   1417702_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110142
Ensembl peptide - ENSMUSP00000062747
Ensembl peptide - ENSMUSP00000110141
NCBI entrez gene - 140483     See in Manteia.
MGI - MGI:2153181
RefSeq - NM_080462
RefSeq - XM_006497670
RefSeq - XM_006497671
RefSeq Peptide - NP_536710
swissprot - A2AQK4
swissprot - Q91VF2
Ensembl - ENSMUSG00000026986
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hnmtENSDARG00000012796Danio rerio
 HNMTENSGALG00000012377Gallus gallus
 HNMTENSG00000150540Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR016673  Histamine N-methyltransferase-like
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001505 regulation of neurotransmitter levels TAS
 biological_processGO:0001695 histamine catabolic process ISO
 biological_processGO:0002347 response to tumor cell IEA
 biological_processGO:0006972 hyperosmotic response IEA
 biological_processGO:0007420 brain development IBA
 biological_processGO:0014075 response to amine IEA
 biological_processGO:0032259 methylation ISO
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0070555 response to interleukin-1 IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0043005 neuron projection IBA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008170 N-methyltransferase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046539 histamine N-methyltransferase activity ISO


Pathways (from Reactome)
Pathway description
Histidine catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001353 increased aggression to other mice "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward other mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
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Allelic Composition: Pabpn1tm2.2Gpvl/Pabpn1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001354 increased aggression towards males "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward male mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
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Allelic Composition: Pabpn1tm2.2Gpvl/Pabpn1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Pabpn1tm2.2Gpvl/Pabpn1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pabpn1tm2.2Gpvl/Pabpn1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002204 abnormal neurotransmitter physiology "aberrant function or production of endogenous signaling molecules secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pabpn1tm2.2Gpvl/Pabpn1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0012289 abnormal non-rapid eye movement sleep pattern "any anomaly in the frequency or duration of the sleep stages characterized by distinct EEG patterns, decreased metabolic activity, slowed breathing and heart rate, and the absence of rapid eye movement and dreaming" [MGI:csmith]
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Allelic Composition: Pabpn1tm2.2Gpvl/Pabpn1+
Genetic Background: involves: C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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