ENSMUSG00000027163


Mus musculus

Features
Gene ID: ENSMUSG00000027163
  
Biological name :Commd9
  
Synonyms : Commd9 / COMM domain-containing protein 9 / Q8K2Q0
  
Possible biological names infered from orthology : COMM domain containing 9 / Q9P000
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E2
Gene start: 101886247
Gene end: 101901646
  
Corresponding Affymetrix probe sets: 10474123 (MoGene1.0st)   1428155_at (Mouse Genome 430 2.0 Array)   1438644_x_at (Mouse Genome 430 2.0 Array)   1454781_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028584
NCBI entrez gene - 76501     See in Manteia.
MGI - MGI:1923751
RefSeq - NM_029635
RefSeq Peptide - NP_083911
swissprot - Q8K2Q0
Ensembl - ENSMUSG00000027163
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 commd9ENSDARG00000094258Danio rerio
 COMMD9ENSGALG00000034859Gallus gallus
 COMMD9ENSG00000110442Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR017920  COMM domain
 IPR037360  COMM domain-containing protein 9


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0042632 cholesterol homeostasis IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxp3tm2.1(EGFP/cre)Shori/Foxp3tm2.1(EGFP/cre)Shori,Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Foxp3tm2.1(EGFP/cre)Shori/Foxp3tm2.1(EGFP/cre)Shori,Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxp3tm2.1(EGFP/cre)Shori/Foxp3tm2.1(EGFP/cre)Shori,Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Foxp3tm2.1(EGFP/cre)Shori/Foxp3tm2.1(EGFP/cre)Shori,Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0001916 intracerebral hemorrhage "bleeding within the cerebrum" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxp3tm2.1(EGFP/cre)Shori/Foxp3tm2.1(EGFP/cre)Shori,Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxp3tm2.1(EGFP/cre)Shori/Foxp3tm2.1(EGFP/cre)Shori,Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0002725 abnormal vein morphology "malformation of the blood vessels that carry blood towards the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxp3tm2.1(EGFP/cre)Shori/Foxp3tm2.1(EGFP/cre)Shori,Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0002740 heart hypoplasia "decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765]
Show

Allelic Composition: Foxp3tm2.1(EGFP/cre)Shori/Foxp3tm2.1(EGFP/cre)Shori,Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Foxp3tm2.1(EGFP/cre)Shori/Foxp3tm2.1(EGFP/cre)Shori,Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0004938 dilated vasculature "stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxp3tm2.1(EGFP/cre)Shori/Foxp3tm2.1(EGFP/cre)Shori,Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Foxp3tm2.1(EGFP/cre)Shori/Foxp3tm2.1(EGFP/cre)Shori,Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Col4a5tm1b(EUCOMM)Wtsi/Col4a5tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col4a5tm1b(EUCOMM)Wtsi/Cnrm

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Col4a5tm1b(EUCOMM)Wtsi/Col4a5tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col4a5tm1b(EUCOMM)Wtsi/Cnrm

 MP:0006085 myocardial necrosis "pathological cell death of the cardiac muscle cells, usually due to irreversible damage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92722]
Show

Allelic Composition: Foxp3tm2.1(EGFP/cre)Shori/Foxp3tm2.1(EGFP/cre)Shori,Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col4a5tm1b(EUCOMM)Wtsi/Col4a5tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col4a5tm1b(EUCOMM)Wtsi/Cnrm

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col4a5tm1b(EUCOMM)Wtsi/Col4a5tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col4a5tm1b(EUCOMM)Wtsi/Cnrm

 MP:0010088 decreased circulating fructosamine level "decrease in the concentration in the blood of total non enzymatic glycated proteins in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col4a5tm1b(EUCOMM)Wtsi/Col4a5tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col4a5tm1b(EUCOMM)Wtsi/Cnrm

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Commd9tm1c(KOMP)Wtsi/Commd9tm1c(KOMP)Wtsi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Foxp3tm2.1(EGFP/cre)Shori/Foxp3tm2.1(EGFP/cre)Shori,Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Col4a5tm1b(EUCOMM)Wtsi/Col4a5tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col4a5tm1b(EUCOMM)Wtsi/Cnrm

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Commd9tm1c(KOMP)Wtsi/Commd9tm1c(KOMP)Wtsi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6N

 MP:0014012 abnormal cranial blood vasculature morphology "any structural anomaly of blood vasculature that is part of a head" [UBERON:0011362]
Show

Allelic Composition: Foxp3tm2.1(EGFP/cre)Shori/Foxp3tm2.1(EGFP/cre)Shori,Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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