ENSMUSG00000027282


Mus musculus

Features
Gene ID: ENSMUSG00000027282
  
Biological name :Mtch2
  
Synonyms : Mitochondrial carrier homolog 2 / Mtch2 / Q791V5
  
Possible biological names infered from orthology : mitochondrial carrier 2 / Q9Y6C9
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E1
Gene start: 90847155
Gene end: 90866810
  
Corresponding Affymetrix probe sets: 10473737 (MoGene1.0st)   10530851 (MoGene1.0st)   1430474_a_at (Mouse Genome 430 2.0 Array)   1430969_at (Mouse Genome 430 2.0 Array)   1437805_at (Mouse Genome 430 2.0 Array)   1437806_x_at (Mouse Genome 430 2.0 Array)   1438842_at (Mouse Genome 430 2.0 Array)   1438843_x_at (Mouse Genome 430 2.0 Array)   1448654_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121851
Ensembl peptide - ENSMUSP00000107092
Ensembl peptide - ENSMUSP00000107093
Ensembl peptide - ENSMUSP00000118566
NCBI entrez gene - 56428     See in Manteia.
MGI - MGI:1929260
RefSeq - XM_017319137
RefSeq - NM_001317241
RefSeq - NM_001317242
RefSeq - NM_001317243
RefSeq - NM_001317244
RefSeq - NM_019758
RefSeq Peptide - NP_001304173
RefSeq Peptide - NP_062732
RefSeq Peptide - NP_001304171
RefSeq Peptide - NP_001304172
RefSeq Peptide - NP_001304170
swissprot - Q9D050
swissprot - D6RCZ1
swissprot - Q791V5
swissprot - A2AFW6
Ensembl - ENSMUSG00000027282
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mtch2ENSDARG00000019732Danio rerio
 MTCH2ENSGALG00000036196Gallus gallus
 MTCH2ENSG00000109919Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mtch1 / Q791T5 / Mus musculus mitochondrial carrier 1 (Mtch1), transcript variant 2, mRNA. / Q9NZJ7* / mitochondrial carrier 1*ENSMUSG0000002401246


Protein motifs (from Interpro)
Interpro ID Name
 IPR018108  Mitochondrial substrate/solute carrier
 IPR023395  Mitochondrial carrier domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006089 lactate metabolic process IMP
 biological_processGO:0010917 negative regulation of mitochondrial membrane potential IMP
 biological_processGO:0035701 hematopoietic stem cell migration IMP
 biological_processGO:0042775 mitochondrial ATP synthesis coupled electron transport IMP
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0045820 negative regulation of glycolytic process IMP
 biological_processGO:0061484 hematopoietic stem cell homeostasis IMP
 biological_processGO:0070585 protein localization to mitochondrion IEA
 biological_processGO:0071478 cellular response to radiation IMP
 biological_processGO:0090152 establishment of protein localization to mitochondrial membrane involved in mitochondrial fission IMP
 biological_processGO:0097284 hepatocyte apoptotic process IGI
 biological_processGO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process IGI
 biological_processGO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane IDA
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA/2

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA/2

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
Show

Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA/2

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA/2

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA/2

 MP:0002582 disorganized extraembryonic tissue "a lack of the regular arrangement of the membranes involved with the embryo s protection and nutrition" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA/2

 MP:0003326 liver failure "cessation of function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA/2

 MP:0005030 absent amnion "missing innermost of the extraembryonic membranes" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA/2

 MP:0009593 absent chorion "absence of the outermost extraembryonic membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA/2

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Apctm1Tno/Apctm1Tno,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA/2

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Mmp9tm1b(EUCOMM)Wtsi/Mmp9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mmp9tm1b(EUCOMM)Wtsi/Ics

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Mmp9tm1b(EUCOMM)Wtsi/Mmp9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mmp9tm1b(EUCOMM)Wtsi/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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