ENSMUSG00000027331


Mus musculus

Features
Gene ID: ENSMUSG00000027331
  
Biological name :Knstrn
  
Synonyms : Knstrn / Q9D9Z1 / Small kinetochore-associated protein
  
Possible biological names infered from orthology : kinetochore localized astrin/SPAG5 binding protein / Q9Y448
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E5
Gene start: 118814003
Gene end: 118853957
  
Corresponding Affymetrix probe sets: 10474825 (MoGene1.0st)   1420081_s_at (Mouse Genome 430 2.0 Array)   1420082_at (Mouse Genome 430 2.0 Array)   1423463_a_at (Mouse Genome 430 2.0 Array)   1423464_at (Mouse Genome 430 2.0 Array)   1442280_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135008
Ensembl peptide - ENSMUSP00000135549
Ensembl peptide - ENSMUSP00000135422
Ensembl peptide - ENSMUSP00000028803
Ensembl peptide - ENSMUSP00000106466
Ensembl peptide - ENSMUSP00000115860
Ensembl peptide - ENSMUSP00000122844
Ensembl peptide - ENSMUSP00000123065
Ensembl peptide - ENSMUSP00000134898
NCBI entrez gene - 51944     See in Manteia.
MGI - MGI:1289298
RefSeq - NM_026412
RefSeq - XM_017319123
RefSeq Peptide - NP_080688
swissprot - H3BJ95
swissprot - H3BJJ3
swissprot - A3KGG8
swissprot - H3BKV9
swissprot - Q9D9Z1
swissprot - H3BKK2
swissprot - A3KGG6
swissprot - F6UVD3
swissprot - F7BE71
Ensembl - ENSMUSG00000027331
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KNSTRNENSGALG00000039576Gallus gallus
 KNSTRNENSG00000128944Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR033373  Small kinetochore-associated protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000070 mitotic sister chromatid segregation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007051 spindle organization IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051988 regulation of attachment of spindle microtubules to kinetochore IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0035371 microtubule plus-end IEA
 cellular_componentGO:0072686 mitotic spindle IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kdm8tm1b(EUCOMM)Wtsi/Kdm8tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kdm8tm1b(EUCOMM)Wtsi/Ics

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Snrktm2Rra/Snrk+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Snrktm2Rra/Snrk+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Snrktm2Rra/Snrk+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Snrktm2Rra/Snrk+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kdm8tm1b(EUCOMM)Wtsi/Kdm8tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kdm8tm1b(EUCOMM)Wtsi/Ics

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Snrktm2Rra/Snrk+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kdm8tm1b(EUCOMM)Wtsi/Kdm8tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kdm8tm1b(EUCOMM)Wtsi/Ics

 MP:0002685 abnormal proliferation of spermatogonia "reduction in the proliferation of the spermatogonial stem cells either due to reduced mitosis or increased apoptosis" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:62271]
Show

Allelic Composition: Snrktm2Rra/Snrk+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Snrktm2Rra/Snrk+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Snrktm2Rra/Snrk+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kdm8tm1b(EUCOMM)Wtsi/Kdm8tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kdm8tm1b(EUCOMM)Wtsi/Ics

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Kdm8tm1b(EUCOMM)Wtsi/Kdm8tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kdm8tm1b(EUCOMM)Wtsi/Ics

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Snrktm2Rra/Snrk+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Snrktm2Rra/Snrk+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kdm8tm1b(EUCOMM)Wtsi/Kdm8tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kdm8tm1b(EUCOMM)Wtsi/Ics

 MP:0013601 increased testis apoptosis "increase in the number of cells of the male reproductive glands undergoing programmed cell death" [MGI:Anna]
Show

Allelic Composition: Snrktm2Rra/Snrk+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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