ENSMUSG00000027338


Mus musculus

Features
Gene ID: ENSMUSG00000027338
  
Biological name :Prnd
  
Synonyms : prion like protein doppel / Prnd / Q9QUG3
  
Possible biological names infered from orthology : Q9UKY0
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F2
Gene start: 131950861
Gene end: 131956130
  
Corresponding Affymetrix probe sets: 10476321 (MoGene1.0st)   1425681_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105798
Ensembl peptide - ENSMUSP00000105799
Ensembl peptide - ENSMUSP00000105800
Ensembl peptide - ENSMUSP00000105801
NCBI entrez gene - 26434     See in Manteia.
MGI - MGI:1346999
RefSeq - NM_001278520
RefSeq - NM_001126338
RefSeq - NM_001278257
RefSeq - NM_023043
RefSeq Peptide - NP_001119810
RefSeq Peptide - NP_001265186
RefSeq Peptide - NP_001265449
RefSeq Peptide - NP_075530
swissprot - Q544A3
swissprot - Q9QUG3
Ensembl - ENSMUSG00000027338
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRNDENSG00000171864Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prn / PRND* / Q9UKY0* / prion like protein doppel*ENSMUSG00000098754100


Protein motifs (from Interpro)
Interpro ID Name
 IPR021566  Prion-like protein Doppel
 IPR022416  Prion/Doppel protein, beta-ribbon domain
 IPR036924  Prion/Doppel beta-ribbon domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006878 cellular copper ion homeostasis IDA
 biological_processGO:0007338 single fertilization IMP
 biological_processGO:0007340 acrosome reaction IMP
 biological_processGO:0051260 protein homooligomerization IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0031362 anchored component of external side of plasma membrane IDA
 molecular_functionGO:0005507 copper ion binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Post-translational modification: synthesis of GPI-anchored proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prndtm1Dwm/Prndtm1Dwm
Genetic Background: 129P2/OlaHsd-Prndtm1Dwm

Allelic Composition: Prnp/Prndtm1Dwm/Prnp/Prndtm1Dwm
Genetic Background: 129P2/OlaHsd-Prnp/Prndtm1Dwm

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: 129X1Bom.129S7-Gnai2tm1Lbi

Allelic Composition: Prndtm1Dwm/Prndtm1Dwm
Genetic Background: 129P2/OlaHsd-Prndtm1Dwm

Allelic Composition: Prnp/Prndtm1Dwm/Prnp/Prndtm1Dwm
Genetic Background: 129P2/OlaHsd-Prnp/Prndtm1Dwm

Allelic Composition: Prnp/Prndtm1Aag/Prnp/Prndtm1Aag
Genetic Background: Not Specified

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: 129X1Bom.129S7-Gnai2tm1Lbi

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: 129X1Bom.129S7-Gnai2tm1Lbi

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: 129X1Bom.129S7-Gnai2tm1Lbi

 MP:0004542 impaired acrosome reaction "abnormality in the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: 129X1Bom.129S7-Gnai2tm1Lbi

Allelic Composition: Prndtm1Dwm/Prndtm1Dwm
Genetic Background: 129P2/OlaHsd-Prndtm1Dwm

Allelic Composition: Prnp/Prndtm1Dwm/Prnp/Prndtm1Dwm
Genetic Background: 129P2/OlaHsd-Prnp/Prndtm1Dwm

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: 129X1Bom.129S7-Gnai2tm1Lbi

Allelic Composition: Prnp/Prndtm1Aag/Prnp/Prndtm1Aag
Genetic Background: Not Specified

 MP:0008898 abnormal acrosome morphology "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]
Show

Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: 129X1Bom.129S7-Gnai2tm1Lbi

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: 129X1Bom.129S7-Gnai2tm1Lbi

 MP:0009243 hairpin sperm flagellum "a structural alteration where the sperm flagellum becomes bent back (folded) on itself to form a hairpin (loop) structure; a sharp hairpin-like bend formation can disrupt the axial structures and cause the sperm tail to become kinked" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: 129X1Bom.129S7-Gnai2tm1Lbi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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