ENSMUSG00000027808


Mus musculus

Features
Gene ID: ENSMUSG00000027808
  
Biological name :Serp1
  
Synonyms : Q9Z1W5 / Serp1 / stress-associated endoplasmic reticulum protein 1
  
Possible biological names infered from orthology : Q9Y6X1
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: D
Gene start: 58519817
Gene end: 58525892
  
Corresponding Affymetrix probe sets: 10498319 (MoGene1.0st)   1415827_a_at (Mouse Genome 430 2.0 Array)   1415828_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029385
NCBI entrez gene - 28146     See in Manteia.
MGI - MGI:92638
RefSeq - NM_030685
RefSeq Peptide - NP_109610
swissprot - Q9Z1W5
Ensembl - ENSMUSG00000027808
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SERP1ENSDARG00000076223Danio rerio
 SERP1ENSGALG00000037325Gallus gallus
 SERP1ENSG00000120742Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Serp2 / Q6TAW2 / Stress-associated endoplasmic reticulum protein 2 / Q8N6R1* / stress associated endoplasmic reticulum protein family member 2*ENSMUSG0000005258489


Protein motifs (from Interpro)
Interpro ID Name
 IPR010580  Stress-associated endoplasmic reticulum protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0006006 glucose metabolic process IMP
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0010259 multicellular organism aging IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IMP
 biological_processGO:0032024 positive regulation of insulin secretion IMP
 biological_processGO:0045727 positive regulation of translation IMP
 biological_processGO:0046622 positive regulation of organ growth IMP
 biological_processGO:0048644 muscle organ morphogenesis IMP
 biological_processGO:0060124 positive regulation of growth hormone secretion IMP
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005881 cytoplasmic microtubule IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
XBP1(S) activates chaperone genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Serp1tm1Hori/Serp1tm1Hori
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Jchaintm3Tl/Jchain+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Serp1tm1Hori/Serp1tm1Hori
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Jchaintm3Tl/Jchain+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Serp1tm1Hori/Serp1tm1Hori
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Jchaintm3Tl/Jchain+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Serp1tm1Hori/Serp1tm1Hori
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002768 small adrenal glands "reduced size of endocrine glands located above the kidneys responsible for hormone and epinephrine secretion" [J:78062]
Show

Allelic Composition: Serp1tm1Hori/Serp1tm1Hori
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002951 small thyroid gland "reduced size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Serp1tm1Hori/Serp1tm1Hori
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Serp1tm1Hori/Serp1tm1Hori
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005120 decreased circulating growth hormone level "less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Serp1tm1Hori/Serp1tm1Hori
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Jchaintm3Tl/Jchain+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Serp1tm1Hori/Serp1tm1Hori
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005361 small pituitary gland "reduced size of the pituitary gland, the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Serp1tm1Hori/Serp1tm1Hori
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008321 small adenohypophysis "reduced size of the anterior part of the pituitary that secretes a variety of hormones" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Serp1tm1Hori/Serp1tm1Hori
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Jchaintm3Tl/Jchain+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Serp1tm1Hori/Serp1tm1Hori
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000052456 Asna1 / O54984 / ATPase Asna1 / O43681* / arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)*  / reaction






 

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