ENSMUSG00000027884


Mus musculus

Features
Gene ID: ENSMUSG00000027884
  
Biological name :Clcc1
  
Synonyms : Clcc1 / Mus musculus chloride channel CLIC-like 1 (Clcc1), transcript variant 4, mRNA. / Q99LI2
  
Possible biological names infered from orthology : chloride channel CLIC like 1 / Q96S66
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F3
Gene start: 108653913
Gene end: 108678840
  
Corresponding Affymetrix probe sets: 10495359 (MoGene1.0st)   1425200_at (Mouse Genome 430 2.0 Array)   1436390_a_at (Mouse Genome 430 2.0 Array)   1436391_s_at (Mouse Genome 430 2.0 Array)   1436730_at (Mouse Genome 430 2.0 Array)   1437511_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029483
Ensembl peptide - ENSMUSP00000102220
Ensembl peptide - ENSMUSP00000102224
Ensembl peptide - ENSMUSP00000118529
NCBI entrez gene - 229725     See in Manteia.
MGI - MGI:2385186
RefSeq - NM_001355632
RefSeq - NM_001177770
RefSeq - NM_001177771
RefSeq - NM_145543
RefSeq - XM_006501416
RefSeq - XM_017319561
RefSeq Peptide - NP_001342561
RefSeq Peptide - NP_663518
RefSeq Peptide - NP_001171241
RefSeq Peptide - NP_001171242
swissprot - Q99LI2
swissprot - A2AEM2
swissprot - Z4YMG1
Ensembl - ENSMUSG00000027884
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU655842.1ENSDARG00000100186Danio rerio
 CLCC1ENSGALG00000002106Gallus gallus
 CLCC1ENSG00000121940Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009231  Chloride channel CLIC-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005254 chloride channel activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000851 cerebellum hypoplasia "reduced cell number in the cerebellum" [MGI:CLS, J:45302]
Show

Allelic Composition: Aldh2tm1.1Mak/Aldh2tm1.1Mak
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Aldh2tm1.1Mak/Aldh2tm1.1Mak
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Aldh2tm1.1Mak/Aldh2tm1.1Mak
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aldh2tm1.1Mak/Aldh2tm1.1Mak
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aldh2tm1.1Mak/Aldh2tm1.1Mak
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004098 abnormal granule neuron "any structural anomaly of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Aldh2tm1.1Mak/Aldh2tm1.1Mak
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Clcc1m1J/Clcc1m1J
Genetic Background: C3H/HeSnJ

 MP:0008025 brain vacuoles "the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aldh2tm1.1Mak/Aldh2tm1.1Mak
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Clcc1m1J/Clcc1m1J
Genetic Background: C3H/HeSnJ

 MP:0008924 decreased granule neuron number "reduction in the number of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
Show

Allelic Composition: Aldh2tm1.1Mak/Aldh2tm1.1Mak
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aldh2tm1.1Mak/Aldh2tm1.1Mak
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0009413 skeletal muscle fiber atrophy "a wasting of skeletal muscle fibers resulting in a derangement of the skeletal muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aldh2tm1.1Mak/Aldh2tm1.1Mak
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0009417 skeletal muscle atrophy "a wasting of skeletal muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Aldh2tm1.1Mak/Aldh2tm1.1Mak
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0020354 increased endoplasmic reticulum stress "increase in in the accumulation of misfolded or unfolded proteins in the endoplasmic reticulum lumen; this accumulation may be stimulated by genetic or enviromental factors" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Aldh2tm1.1Mak/Aldh2tm1.1Mak
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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