MP:0000141 | abnormal vertebral body morphology | "malformed main portion of the vertebra anterior to the vertebral canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0000273 | overriding aorta | "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0000282 | abnormal atrial septum morphology | "abnormality in the wall between the atria of the heart, usually incomplete closure " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0000297 | abnormal endocardial cushion morphology | "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0000602 | enlarged sinusoidal spaces | "larger than normal sized cavities in the liver " [J:23170] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0000632 | abnormal pineal gland morphology | "anomalous structure of the small, flattened body located in the depression between the superior colliculi and which produces melatonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0000783 | abnormal forebrain morphology | "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0000788 | abnormal cerebral cortex morphology | "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0000841 | abnormal hindbrain morphology | "malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0000963 | fused dorsal root ganglia | "loss of DRG spacing pattern and the appearance of two or more ganglia as one " [J:62022, J:62023] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0001015 | small superior cervical ganglion | "reduced size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [J:23882] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0001303 | abnormal lens morphology | "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0002249 | abnormal larynx morphology | "any structural anomaly of the most superior portion of the respiratory tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0003105 | abnormal heart atrium morphology | "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0003130 | anal atresia | "absence of a connection between the anal pit and the rectum" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91491] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0003262 | intestinal/bowel diverticulum | "a pouch or sac protruding from the intestinal or bowel wall " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0003617 | urinary bladder hypoplasia | "reduced number of cells comprising the urinary bladder, often resulting in a small size" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0003686 | abnormal eye muscle morphology | "malformation of the muscles of the eye" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0003826 | abnormal Mullerian duct morphology | "malformation of the transient embryonic tubes that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0003922 | abnormal right atrium morphology | "structural anomaly of the right upper chamber of the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0004158 | right aortic arch | "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0004160 | retroesophageal right subclavian artery | "the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0004599 | abnormal vertebral arch morphology | "any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0004603 | absent vertebral arch | "loss of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0004613 | fusion of vertebral arches | "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0005012 | decreased eosinophil count | "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: C1ql3tm1.2Sud/C1ql3+ Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL
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MP:0005018 | decreased T cell number | "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: C1ql3tm1.2Sud/C1ql3+ Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL
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MP:0006065 | abnormal heart position | "the heart is displaced from the normal left-sided position and/or orientation" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0006093 | arteriovenous malformation | "fusion of an artery and vein without an intervening capillary bed" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93125] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0006408 | dorsal root ganglion hypoplasia | "underdevelopment or reduced size, usually due to a reduced cell number, of a dorsal root ganglion or ganglia" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0008075 | decreased CD4-positive T cell number | "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: C1ql3tm1.2Sud/C1ql3+ Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL
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MP:0008128 | abnormal brain internal capsule morphology | "any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0008347 | decreased gamma-delta T cell number | "reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149] |
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Allelic Composition: C1ql3tm1.2Sud/C1ql3+ Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL
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MP:0010200 | enlarged lymphatic vessel | "increased size of the network of vessels which carries lymph around the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0010418 | perimembraneous ventricular septal defect | "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0010420 | muscular ventricular septal defect | "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0010490 | abnormal inferior vena cava valve morphology | "any structural anomaly of the semicircular fold of endocardium located on the right atrium at the point of attachment of the inferior vena cava" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0010496 | abnormal pectinate muscle morphology | "any structural anomaly of the prominent ridges of atrial myocardium located on the inner surface of most of the right atrium and both the right and left auricular regions" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0010595 | abnormal aortic valve cusp morphology | "any structural anomaly of the three fibrous triangular components and associated flap of the aortic valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0010602 | abnormal pulmonary valve cusp morphology | "any structural anomaly of the three fibrous triangular components and associated flap of the pulmonary valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0010912 | herniated liver | "protrusion of any portion of the liver from its normal anatomical position" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0011493 | double ureter | "two ureters open separately into the renal pelvis superiorly and drain separately into the urinary bladder or genital tract; if two ureteral buds arise from the Wolffian duct, a duplex kidney with complete ureteral duplication ensues" [http://emedicine.medscape.com/article/378075-overview, MGI:anna] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0012765 | decreased alpha-beta T cell number | "reduced number of T cells that expresses an alpha-beta T cell receptor complex" [CL:0000789] |
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Allelic Composition: C1ql3tm1.2Sud/C1ql3+ Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL
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MP:0013022 | increased Ly6C high monocyte number | "increase in the number of monocytes that express high levels of Ly6C and low MHC class II that represent a subset of circulating inflammatory monocytes that are recruited to infected or inflamed tissues" [MGI:Annie_Speak] |
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Allelic Composition: C1ql3tm1.2Sud/C1ql3+ Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL
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MP:0013026 | decreased Ly6C low monocyte number | "decrease in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [MGI:Annie_Speak] |
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Allelic Composition: C1ql3tm1.2Sud/C1ql3+ Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL
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MP:0013826 | absent hypoglossal canal | "absence of the bony canal in the occipital bone through which the hypoglossal nerve emerges from the skull" [ISBN:0683400088] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0013834 | thin hypoglossal nerve | "slender appearance of the motor nerve which innervates all the intrinsic and all but one of the extrinsic muscles of the tongue" [ISBN:0-683-40008-8] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0013835 | absent hypoglossal nerve | "absence of the motor nerve which innervates all the intrinsic and all but one of the extrinsic muscles of the tongue" [ISBN:0-683-40008-8] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0013836 | abnormal hypoglossal nerve topology | "abnormal position of the hypoglossal nerve " [MGI:csmith] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0013840 | absent segment of posterior cerebral artery | "absence of a portion of one of a pair of blood vessels that supplies oxygenated blood to the posterior aspect of the brain" [UBERON:0001636] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0013848 | subcutaneous edema | "accumulation of watery or serous fluid in the subcutaneous region below the skin" [MGI:csmith] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0013859 | abnormal vitelline vein connection | "aberrant or missing attachment of the paired veins that carry blood from the yolk sac back to the embryo" [ISBN:0-683-40008-8, MGI:csmith] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0013876 | absent ductus venosus valve | "absence of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0013877 | abnormal ductus venosus valve morphology | "any structural anomaly of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0013878 | abnormal ductus venosus valve topology | "abnormal position of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0013913 | absent rib-vertebral column attachment | "one or more ribs are not connected to vertebra, where this connection is normally made" [MGI:csmith] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0013924 | abnormal dural venous sinus morphology | "any structural anomaly of the endothelium-lined venous channels in the dura mater" [ISBN:0-683-40008-8] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0013937 | absent lobe of thyroid gland | |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0013952 | retro-esophageal left subclavian artery | |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0013967 | abnormal infrahyoid muscle connection | |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0013969 | reduced sympathetic cervical ganglion size | |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0013971 | blood in lymph vessels | |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0014001 | abnormal vertebral artery topology | "abnormal position of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck" [MGI:csmith] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0014017 | abnormal Wolffian duct connection | "aberrant attachment or incomplete connection of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) to the cloaca " [ISBN:0-683-40008-8] |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0014019 | embryo cyst | |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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MP:0014021 | heterochrony | |
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust
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