ENSMUSG00000027944


Mus musculus

Features
Gene ID: ENSMUSG00000027944
  
Biological name :Hax1
  
Synonyms : Hax1 / HCLS1-associated protein X-1 / O35387
  
Possible biological names infered from orthology : O00165
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F1
Gene start: 89995446
Gene end: 89998780
  
Corresponding Affymetrix probe sets: 10478938 (MoGene1.0st)   10499705 (MoGene1.0st)   1426187_a_at (Mouse Genome 430 2.0 Array)   1438180_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078661
Ensembl peptide - ENSMUSP00000143663
Ensembl peptide - ENSMUSP00000143557
Ensembl peptide - ENSMUSP00000143155
Ensembl peptide - ENSMUSP00000143136
Ensembl peptide - ENSMUSP00000142741
Ensembl peptide - ENSMUSP00000142627
Ensembl peptide - ENSMUSP00000142445
NCBI entrez gene - 23897     See in Manteia.
MGI - MGI:1346319
RefSeq - XM_017319570
RefSeq - NM_001282032
RefSeq - NM_001310681
RefSeq - NM_011826
RefSeq - XM_006501446
RefSeq - XM_017319569
RefSeq Peptide - NP_001297610
RefSeq Peptide - NP_035956
RefSeq Peptide - NP_001268961
swissprot - B9EJR4
swissprot - A0A0G2JGG5
swissprot - A0A0G2JFF9
swissprot - A0A0G2JFE1
swissprot - A0A0G2JEE6
swissprot - A0A0G2JDP0
swissprot - A0A0G2JE46
swissprot - A0A0G2JGR0
swissprot - O35387
Ensembl - ENSMUSG00000027944
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hax1ENSDARG00000036764Danio rerio
 HAX1ENSG00000143575Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR017248  HS1-associating protein X-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0030833 regulation of actin filament polymerization IEA
 biological_processGO:0030854 positive regulation of granulocyte differentiation ISO
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0071345 cellular response to cytokine stimulus ISO
 biological_processGO:2000251 positive regulation of actin cytoskeleton reorganization ISO
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane ISO
 cellular_componentGO:0005758 mitochondrial intermembrane space ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum IEA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019966 interleukin-1 binding ISO
 molecular_functionGO:0047485 protein N-terminus binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000061 fragile skeleton "easily damaged or broken bones" [J:14208]
Show

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Atp7aMo-Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-Btlr

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atp7aMo-Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-Btlr

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Atp7aMo-Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-Btlr

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ghrtm1.1Dlr/Ghrtm1.1Dlr,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * DBA

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Atp7aMo-Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-Btlr

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0001428 adipsia "absence of thirst or lack of desire to drink " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
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Allelic Composition: Atp7aMo-Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-Btlr

 MP:0001438 aphagia "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
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Allelic Composition: Atp7aMo-Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-Btlr

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-Btlr

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-Btlr

Allelic Composition: Hax1tm1Jni/Hax1tm1Jni,Bak1tm1Thsn/Bak1tm1Thsn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Hax1tm1Jni/Hax1tm1Jni
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Atp7aMo-Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-Btlr

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp7aMo-Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-Btlr

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Atp7aMo-Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-Btlr

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atp7aMo-Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-Btlr

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atp7aMo-Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-Btlr

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Atp7aMo-Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-Btlr

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp7aMo-Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-Btlr

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp7aMo-Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-Btlr

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0009923 decreased transitional stage T1 B cell number "reduced number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]
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Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0009926 decreased transitional stage T2 B cell number "reduced number of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]
Show

Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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