ENSMUSG00000028003


Mus musculus

Features
Gene ID: ENSMUSG00000028003
  
Biological name :Lrat
  
Synonyms : Lecithin retinol acyltransferase / Lrat / Q9JI60
  
Possible biological names infered from orthology : O95237
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: E3
Gene start: 82892579
Gene end: 82903973
  
Corresponding Affymetrix probe sets: 10498978 (MoGene1.0st)   1421345_at (Mouse Genome 430 2.0 Array)   1444487_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029632
NCBI entrez gene - 79235     See in Manteia.
MGI - MGI:1891259
RefSeq - NM_023624
RefSeq Peptide - NP_076113
swissprot - B2RUR5
swissprot - Q9JI60
Ensembl - ENSMUSG00000028003
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrataENSDARG00000037278Danio rerio
 LRATENSGALG00000009276Gallus gallus
 LRATENSG00000121207Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007053  LRAT-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006653 1,2-diacyl-sn-glycero-3-phosphocholine metabolic process TAS
 biological_processGO:0006776 vitamin A metabolic process IDA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0032370 positive regulation of lipid transport IGI
 biological_processGO:0042572 retinol metabolic process ISS
 biological_processGO:0042573 retinoic acid metabolic process IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005771 multivesicular body IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0001972 retinoic acid binding IEA
 molecular_functionGO:0008374 O-acyltransferase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0019841 retinol binding IEA
 molecular_functionGO:0047173 phosphatidylcholine-retinol O-acyltransferase activity ISO
 molecular_functionGO:0102279 lecithin:11-cis retinol acyltransferase activity IEA


Pathways (from Reactome)
Pathway description
The canonical retinoid cycle in rods (twilight vision)
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001004 abnormal photoreceptor morphology "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pkd1tm1Hung/Pkd1tm1Hung
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Lrattm1Kpal/Lrattm1Kpal,Rhotm1.1Kpal/Rho+,Rpe65450L/Rpe65450M
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0001327 reduced retinal photoreceptor cell number "fewer than the expected number of rods and/or cones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lrattm1Kpal/Lrattm1Kpal,Rhotm1.1Kpal/Rho+,Rpe65450L/Rpe65450M
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0001940 testicular hypoplasia "decreased cell number in the testicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pkd1tm1Hung/Pkd1tm1Hung
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Pkd1tm1Hung/Pkd1tm1Hung
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Pkd1tm1Hung/Pkd1tm1Hung
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Tg(CMV-cre)1Cgn/0,Trp53tm2Att/Trp53+
Genetic Background: involves: 129S4/SvJae * BALB/cJ

Allelic Composition: Lrattm1.1Bok/Lrattm1.1Bok
Genetic Background: involves: 129S2/SvPas

 MP:0008444 retinal cone cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

 MP:0008449 abnormal retinal cone cell outer segment morphology "any structural anomaly of the retinal cone cell region in which the visual pigment rhodopsin is in invaginations of the cell membrane" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

Allelic Composition: Lrattm1Kpal/Lrattm1Kpal,Rhotm1.1Kpal/Rho+,Rpe65450L/Rpe65450M
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Lrattm1Kpal/Lrattm1Kpal,Rhotm2.1Kpal/Rhotm2.1Kpal
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0008451 retinal rod cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

Allelic Composition: Lrattm1Kpal/Lrattm1Kpal,Rhotm1.1Kpal/Rho+,Rpe65450L/Rpe65450M
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0008456 abnormal retinal rod cell outer segment morphology "any strucutral anomaly of the retinal rod cell region which contains stacks of membranous discs separate from the outer cell membrane that are rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lrattm1Kpal/Lrattm1Kpal,Rhotm1.1Kpal/Rho+,Rpe65450L/Rpe65450M
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

Allelic Composition: Lrattm1Kpal/Lrattm1Kpal,Rhotm1.1Kpal/Rho+,Rpe65450L/Rpe65450M
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Lrattm1Kpal/Lrattm1Kpal,Rhotm2.1Kpal/Rhotm2.1Kpal
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0008587 short photoreceptor outer segment "decreased length of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

Allelic Composition: Lrattm1Bok/Lrattm1Bok,Tg(Tyrp1-cre)1Ipc/?
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Lrattm1.1Bok/Lrattm1.1Bok
Genetic Background: involves: 129S2/SvPas

 MP:0009257 dilated seminiferous tubules "the luminal space of the seminiferous tubules is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pkd1tm1Hung/Pkd1tm1Hung
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Krit1tm1.1(KOMP)Vlcg/Krit1+
Genetic Background: C57BL/6N-Krit1tm1.1(KOMP)Vlcg/Ucd

 MP:0011232 abnormal vitamin A level "any anomaly in the concentration of any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid; animals can not synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids supplied in the diet" [GO:0035238]
Show

Allelic Composition: Pkd1tm1Hung/Pkd1tm1Hung
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

Allelic Composition: Lrattm1Bok/Lrattm1Bok,Tg(Tyrp1-cre)1Ipc/?
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Lrattm1.1Bok/Lrattm1.1Bok
Genetic Background: involves: 129S2/SvPas

 MP:0011233 abnormal vitamin A metabolism "altered ability to metabolize any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid; animals can not synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids supplied in the diet" [GO:0035238]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

 MP:0011234 abnormal retinol level "any anomaly in the concentration of retinol, which plays an essential role in metabolic functioning of the retina, and growth and differentiation" [ISBN:0-683-40008-8]
Show

Allelic Composition: Pkd1tm1Hung/Pkd1tm1Hung
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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