ENSMUSG00000028096


Mus musculus

Features
Gene ID: ENSMUSG00000028096
  
Biological name :Gpr89
  
Synonyms : Gpr89 / G protein-coupled receptor 89 / Q8BS95
  
Possible biological names infered from orthology : B7ZAQ6 / GPR89A / GPR89B / G protein-coupled receptor 89A / G protein-coupled receptor 89B / P0CG08
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F2.1
Gene start: 96868281
Gene end: 96905346
  
Corresponding Affymetrix probe sets: 10500412 (MoGene1.0st)   1424696_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116016
Ensembl peptide - ENSMUSP00000029738
NCBI entrez gene - 67549     See in Manteia.
MGI - MGI:1914799
RefSeq - NM_026229
RefSeq - XM_017319696
RefSeq Peptide - NP_080505
swissprot - D6RI66
swissprot - Q8BS95
Ensembl - ENSMUSG00000028096
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GPR89AENSDARG00000077983Danio rerio
 GPR89BENSGALG00000015491Gallus gallus
 B7ZAQ6ENSG00000117262Homo sapiens
 GPR89BENSG00000188092Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015672  The Golgi pH regulator/GPCR-type G protein
 IPR022535  Golgi pH regulator, conserved domain
 IPR025969  Abscisic acid G-protein coupled receptor-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0015698 inorganic anion transport IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0043588 skin development IMP
 biological_processGO:0051452 intracellular pH reduction IBA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030660 Golgi-associated vesicle membrane ISO
 cellular_componentGO:0032580 Golgi cisterna membrane IBA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0008308 voltage-gated anion channel activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Map3k14tm1Rds/Map3k14tm1Rds,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Map3k14tm1Rds/Map3k14tm1Rds,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0000652 enlarged sebaceous gland "increased size of the sebum secreting glands of the hair shaft" [J:30249]
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Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Map3k14tm1Rds/Map3k14tm1Rds,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
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Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Map3k14tm1Rds/Map3k14tm1Rds,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Map3k14tm1Rds/Map3k14tm1Rds,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Map3k14tm1Rds/Map3k14tm1Rds,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Map3k14tm1Rds/Map3k14tm1Rds,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Map3k14tm1Rds/Map3k14tm1Rds,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Map3k14tm1Rds/Map3k14tm1Rds,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Map3k14tm1Rds/Map3k14tm1Rds,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Map3k14tm1Rds/Map3k14tm1Rds,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Map3k14tm1Rds/Map3k14tm1Rds,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Map3k14tm1Rds/Map3k14tm1Rds,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0003677 abnormal ear lobe "anomaly in the soft tissue at the base of the outer ear; consists of fat and fibrous tissue not reinforced by the auricular cartilage " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Map3k14tm1Rds/Map3k14tm1Rds,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0003936 abnormal reproductive system development "developmental anomaly of any of the organs involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Map3k14tm1Rds/Map3k14tm1Rds,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0003941 abnormal skin development "anomaly in the formation of of the membranous protective covering of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Map3k14tm1Rds/Map3k14tm1Rds,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0005408 hypopigmentation "dilution of the pigment in the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Map3k14tm1Rds/Map3k14tm1Rds,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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